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Trial record 35 of 228 for:    yeast

Immunological Interaction Between the Host and Candida Albicans Biofilm

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT01919931
Recruitment Status : Completed
First Posted : August 9, 2013
Last Update Posted : December 7, 2016
Sponsor:
Information provided by (Responsible Party):
Universitaire Ziekenhuizen Leuven

Brief Summary:
Candida albicans is one of the most common nosocomial infection and the onset relies on the host immune status. The purpose of this study is to determine the immunological profile of patients infected with Candida albicans, that could ideally lead to a strategy to identify patients who could benefit from prophylaxis.

Condition or disease
Candidiasis

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Study Type : Observational
Actual Enrollment : 237 participants
Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Immunological and Molecular Interaction Between the Host and Candida Albicans Biofilm
Study Start Date : March 2013
Actual Primary Completion Date : August 2015
Actual Study Completion Date : January 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Yeast Infections

Group/Cohort
Candida Infection
Patients infected with Candida albicans
No infection
Patients with no Candida albicans infection



Primary Outcome Measures :
  1. Immunological phenotyping of patients [ Time Frame: 2 months ]

Secondary Outcome Measures :
  1. Mannose Binding Lectin levels [ Time Frame: 1 month ]

Biospecimen Retention:   None Retained
Samples to be retained: whole blood, Plasma and White cells.


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients with Candida albicans infection. Patients with no Candida albicans infection. Healthy volunteers
Criteria

Inclusion Criteria:

  • Patients infected with Candida albicans
  • Patients not infected with Candida albicans

Exclusion Criteria:

  • Underage patients
  • Non consenting patients
  • Unconscious patients

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01919931


Locations
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Belgium
Universitair Ziekenhuis Leuven
Leuven, Flemish Brabant, Belgium, 3000
Sponsors and Collaborators
Universitaire Ziekenhuizen Leuven
Investigators
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Study Director: Adrian Liston, Group Leader Flemish Institute of Biotechnology

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Responsible Party: Universitaire Ziekenhuizen Leuven
ClinicalTrials.gov Identifier: NCT01919931     History of Changes
Other Study ID Numbers: S55012
First Posted: August 9, 2013    Key Record Dates
Last Update Posted: December 7, 2016
Last Verified: December 2016
Keywords provided by Universitaire Ziekenhuizen Leuven:
Candida albicans
Candidiasis
Biofilm
Flow cytometry
Mannose Binding Lectin
Additional relevant MeSH terms:
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Candidiasis
Mycoses