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Circulating Endothelial Progenitor Cells and Aortic Aneurysm (ANOPEC3)

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ClinicalTrials.gov Identifier: NCT01918982
Recruitment Status : Unknown
Verified August 2013 by Prof. Sidney Chocron, Hopital Jean Minjoz.
Recruitment status was:  Not yet recruiting
First Posted : August 8, 2013
Last Update Posted : August 8, 2013
Sponsor:
Information provided by (Responsible Party):
Prof. Sidney Chocron, Hopital Jean Minjoz

Brief Summary:
We aimed to see if aortic aneurysms could be followed-up by circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- blood level.

Condition or disease
- Aortic Aneurysm

Detailed Description:
Circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- have been shown to be inversely correlated to aortic aneurysm size. We aimed to see if aortic aneurysms could be followed-up by circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- blood level. 40 patients followed for known aortic aneurysm >30mm and <50mm will be followed up every 6 months during 2 years. Each 6 months they will have a consultation by their physiologist with an echo or a CT-scan. At the same time, a 10ML blood sample will be taken to assess the circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- blood level.

Study Type : Observational
Estimated Enrollment : 40 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Interest of Circulating Endothelial Progenitor Cells CD34+144+CD14- and CD34+VEGF-R2+CD14- in the Follow-up of Aortic Aneurysm
Study Start Date : October 2013
Estimated Primary Completion Date : February 2016
Estimated Study Completion Date : May 2016

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Group/Cohort
Aortic aneurysm
Patients with aortic aneurysm >30mm and < 50mm



Primary Outcome Measures :
  1. Circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- blood concentration [ Time Frame: 2 years ]
    Patients are followed for 2 years



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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with aortic aneurysm
Criteria

Inclusion Criteria:

  • Aortic aneurysm size >30mm and > 50mm

Exclusion Criteria:

  • Infectious disease
  • Inflammatory disease
  • Liver insuffisency
  • Cancer evolutive
  • Pregnant women

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01918982


Contacts
Contact: Sidney Chocron +33381533121 sidney.chocron@univ-fcomte.fr

Sponsors and Collaborators
Hopital Jean Minjoz
Investigators
Principal Investigator: Sidney Chocron, MD, PhD Université de Franche-comté. France
Principal Investigator: Andrea Perrotti, MD Université de Franche-Comté. France
Principal Investigator: Simon Rinckenbach, MD, PhD Université de Franche-Comté. France
Principal Investigator: Siamak Davani, MD, PhD Université de Franche-Comté. France

Publications:
Responsible Party: Prof. Sidney Chocron, MD, PhD, Hopital Jean Minjoz
ClinicalTrials.gov Identifier: NCT01918982     History of Changes
Other Study ID Numbers: 147/362
First Posted: August 8, 2013    Key Record Dates
Last Update Posted: August 8, 2013
Last Verified: August 2013

Keywords provided by Prof. Sidney Chocron, Hopital Jean Minjoz:
Aortic aneurysm
circulating endothelial progenitor cells

Additional relevant MeSH terms:
Aneurysm
Aortic Aneurysm
Vascular Diseases
Cardiovascular Diseases
Aortic Diseases