Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility.
Recruitment status was Not yet recruiting
Some animal studies revealed that the pomegranate juice may improve sperm quality in terms of concentration, motility and morphology, as well as in fertilization rate.
Minor data is available regarding the influence on male sperm.
Male Infertility With Severe Oligo-terato-asteno-spermia
Dietary Supplement: Pomegranate pills
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Factorial Assignment
Masking: Open Label
Primary Purpose: Supportive Care
|Official Title:||Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility.|
- pregnancy [ Time Frame: 24 month ] [ Designated as safety issue: No ]
- ROS (reactive oxidative stress )and Interleukins level in semen fluid [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]The unit for measure the ROS are Micromolar epicatechin equivalent
|Study Start Date:||September 2013|
|Estimated Study Completion Date:||September 2014|
|Estimated Primary Completion Date:||September 2014 (Final data collection date for primary outcome measure)|
No Intervention: No Pills
Patients in this group will not receive Pomegranate pills.
Active Comparator: Pomegranate pills
The reccruited patient will receive pomegranate pills every day for 12 weeks. The control group will not be exposed for the pills.
|Dietary Supplement: Pomegranate pills|
Pomegranate contains a high concentration of vitamins ( C, B1, B2, B3, B5), potassium, Magnesium , Zinc and is a good source for polyphenols .Polyphenols molecules have been found to possess antioxidant properties and may effects the expression of different genes . Recent studies indicate that among foods that contain polyphenols, juice extracted from the pomegranate has the highest concentration of measurable polyphenols . Pomegranates have shown inhibitory effect on NF-κB and the MAP kinases JNK and ERK, which are critical steps in the cascade of events leading to inflammatory response. The NF- κB pathway is activated in response to bacterial infection and initiates the inflammatory cascade, which may explain the protective effect of Pomegranates on bacterial infections.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01918163
|Contact: Einat Shalom-Paz, MDfirstname.lastname@example.org|
|Contact: Ellenbogen Adrian, MDemail@example.com|
|Hillel Yaffe Medical Center||Not yet recruiting|
|Hadera, Israel, 38100|
|Contact: Reuma Barkan 97246304223 firstname.lastname@example.org|
|Principal Investigator:||Einat Shalom-Paz, MD||Hillel Yaffe Medical center, IVF unit, Hadera, Israel|