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Cardiac MRI in Ischemic Stroke Study (CaMriSS)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01917955
First Posted: August 7, 2013
Last Update Posted: November 8, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Center for Stroke Research Berlin
Cardiology and Angiology, Elisabeth Hospital, Essen, Germany
Information provided by (Responsible Party):
Karl Georg Haeusler, Charite University, Berlin, Germany
  Purpose
The purpose of this prospective single-center trial is to compare the safety and diagnostic value of contrast medium-enhanced cardiac magnetic resonance imaging and transesophageal echocardiography in patients with acute ischemic stroke.

Condition
Stroke

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Cardiac MRI in Ischemic Stroke Study

Further study details as provided by Karl Georg Haeusler, Charite University, Berlin, Germany:

Primary Outcome Measures:
  • Sensitivity and specificity of contrast medium-enhanced cardiac magnetic resonance imaging to detect echocardiography-proven cardiac sources of embolism in patients with acute ischemic stroke. [ Time Frame: < 1 week after ischemic stroke ]

Secondary Outcome Measures:
  • Rate of unrecognised myocardial infarction detected by late gadolinium-enhanced cardiac MRI in patients with acute ischemic stroke. [ Time Frame: < 1 week after ischemic stroke ]

Enrollment: 103
Study Start Date: January 2012
Study Completion Date: November 2014
Primary Completion Date: November 2014 (Final data collection date for primary outcome measure)
Detailed Description:
Primary safety objective: Contrast medium-enhanced cardiac magnetic resonance imaging is safe in patients with acute ischemic stroke. Primary outcome: The diagnostic value of contrast medium-enhanced cardiac magnetic resonance imaging is comparable to transesophageal echocardiography in patients with acute ischemic stroke.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Overall, 103 patients with acute ischemic stroke detected by brain magnetic resonance imaging will be enrolled.
Criteria

Inclusion Criteria:

  • Patients with acute ischemic stroke detected by brain magnetic resonance imaging.

Exclusion Criteria:

  • Known atrial fibrillation or cardiac source of embolism
  • Severe aphasia
  • Acute infection or chronic inflammation
  • Severe arteriosclerosis or stenosis of brain-supplying arteries
  • Contraindications for magnetic resonance imaging or transesophageal echocardiography.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01917955


Locations
Germany
Charité, Universitätsmedizin Berlin, Campus Benjamin Franklin
Berlin, Germany, 12203
Elisabeth Hospital
Essen, Germany
Sponsors and Collaborators
Charite University, Berlin, Germany
Center for Stroke Research Berlin
Cardiology and Angiology, Elisabeth Hospital, Essen, Germany
Investigators
Study Chair: Prof. Matthias Endres, MD Center for Stroke Research Berlin
Principal Investigator: Karl Georg Haeusler, MD Center for Stroke Research Berlin
  More Information

Responsible Party: Karl Georg Haeusler, MD, Charite University, Berlin, Germany
ClinicalTrials.gov Identifier: NCT01917955     History of Changes
Other Study ID Numbers: CaMriSS_CSB
EA4/073/10 ( Other Identifier: Charité Ethics Committee )
First Submitted: August 7, 2012
First Posted: August 7, 2013
Last Update Posted: November 8, 2016
Last Verified: November 2016

Keywords provided by Karl Georg Haeusler, Charite University, Berlin, Germany:
MRI

Additional relevant MeSH terms:
Stroke
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases