Micro Array Analysis in Preeclampsia
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|ClinicalTrials.gov Identifier: NCT01914809|
Recruitment Status : Recruiting
First Posted : August 2, 2013
Last Update Posted : July 7, 2016
Preeclampsia is a frequent pathology. His etiology is doubtful.
The study target is to identify a risk of preeclampsia group obtained with transcriptom analysis from circulating peripheric cells.
Multidisciplinary study (Gynaecology-Obstetric, Immunology, North CIC).
The study of the transcriptional history of peripheral blood cells of 2patients groups:
- A patient group with a preeclampsia before 34 SA
- A patient group with a normal pregnancy paired on main confusion factors. Blood sampling will be collected at the diagnosis and 8 weeks after delivery.
Results and perspectives
- Obtain a transcriptionnal signature of preeclampsia
- To identify new mechanism of the disease
- Identification of a specific transcriptom analysis with the comparison after delivery For long-term, the target is to identify risk patient in order to conduct easily preventive clinical trials in preeclamsia (primary prevention) and to consider a specific follow-up for risk patients.
|Condition or disease||Intervention/treatment|
|Preeclampsia||Other: samples blood Other: biopsy placentaire|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||40 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Micro Array Analysis in Preeclampsia|
|Study Start Date :||January 2011|
|Estimated Primary Completion Date :||January 2017|
|Estimated Study Completion Date :||June 2017|
|Experimental: group with a preeclampsia before 34 SA||Other: samples blood Other: biopsy placentaire|
|group with a normal pregnancy||Other: samples blood Other: biopsy placentaire|
- predictive markers of preeclampsia [ Time Frame: 36 months ]blood samples
- analysis of placental transcriptional profile. [ Time Frame: 36 months ]biopsie placentaire
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01914809
|Contact: florence firstname.lastname@example.org|
|Assistance Publique Hopitaux de Marseille||Recruiting|
|Marseille, France, 13354|
|Contact: florence bretelle email@example.com|
|Principal Investigator: florence bretelle|
|Study Director:||LOIC MONDOLONI||Assistance Publique Hopitaux De Marseille|