The Impact of Epidural Steroid Analgesia on Functional MRI for Patients With LBP
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|ClinicalTrials.gov Identifier: NCT01913782|
Recruitment Status : Completed
First Posted : August 1, 2013
Last Update Posted : June 19, 2018
Chronic low back pain (CLBP) is the most prevalent form of chronic pain, and the most common reason for disability in working-age population . CLBP has also been reported associated with many abnormal brain anatomy and function which includes the reduction in cortical gray matter in the bilateral dorsolateral prefrontal cortex (DLPFC), thalamus, brain stem, primary somatosensory cortex, and posterior parietal cortex. [3-5] There are already many studies that demonstrated abnormal cortical function for people with CLBP [6-10]. Meanwhile, DLPFC was also reported to be influenced by many pain process which included pain modulation [11-13], placebo analgesia [14, 15], pain control [16, 17]or pain catastrophizing. And recent report has showed that effective treatment of chronic back pain patients reverses abnormal DLPFC function. Meanwhile, epidural steroid injection has been performed in clinical for routinely managed for low back pain patients. Patients refused or have no indication for surgery or have little response to rehabilitation may consider this management. There was good evidence for short- and long-term relief of chronic pain secondary to disc herniation with local anesthetic and steroids[20, 21]. However, the impact of this treatment on functionalMRI (fMRI) has never been investigated. The investigators research will try to solve this issue.
This study will provide a good relationship for the pain fMRI image in brain after local lumbar spine management. And the investigators also want to perform the first data that showed local lumbar analgesia have the impact on brain image change.
|Condition or disease|
|Chronic Low Back Pain|
|Study Type :||Observational|
|Actual Enrollment :||7 participants|
|Official Title:||The Impact of Epidural Steroid Analgesia on Functional MRI for Patients With Low Back Pain|
|Actual Study Start Date :||October 2012|
|Actual Primary Completion Date :||April 2018|
|Actual Study Completion Date :||June 2018|
patients with low back pain
- The pain fMRI image in brain after local lumbar spine [ Time Frame: 14 months ]
Biospecimen Retention: None Retained
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01913782
|National Cheng Kung University Hospital|
|Tainan City, Shengli Rd, Taiwan, 701|
|Study Chair:||Yen-Chin Liu, Doctor||Department of Anesthesiology, National Cheng-Kung University Hospital|