Postural Responses to External Perturbation in Post-Stroke
Recruitment status was Not yet recruiting
To maintain stable body balance in daily activities, the ability to respond to external perturbations is an essential factor. Such capacity is limited in pathological conditions, such as in stroke, in which postural control is impaired due to lesions to the central nervous system. Impairment to postural control increases body sway during upright posture and leads to augmented frequency of falls. In this sense, the identification of mechanisms involved in body balance disorders after stroke is particularly important in situations of postural perturbation. The purpose of this project is to evaluate reactive postural responses to unpredictable external perturbations, analyzing postural dysfunctions caused by lesion to different brain areas as a result of stroke, and test principles of dynamic body balance rehabilitation.
|Study Design:||Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Postural Responses to External Perturbation in Post-Stroke: Sensorimotor Integration and Rehabilitation|
- Displacement amplitude of the CP to the anterior-posterior and medial-lateral [ Time Frame: 2 months ] [ Designated as safety issue: Yes ]This outcome measure quantified by the difference between the maximum values of the anterior-posterior and medial-lateral after the start of trial and average position in the axis anteroposterior and mediolateral, respectively, in the 200 ms prior to the onset of the trial.
- Coordination between the hip and ankle joint [ Time Frame: 2 months ] [ Designated as safety issue: Yes ]Coordination between the hip and ankle joints, which is evaluated by adjusting the angle displacement data, hip and ankle angle within 95% of an ellipse surrounding the values of the disturbance moment until the end of the trial. Will be carried out a regression analysis to identify the slope of the fitted ellipse. Slopes greater indicate a greater share of the ankle in relation to the hip
- Muscle activation latency [ Time Frame: 2 months ] [ Designated as safety issue: Yes ]This outcome measure is time between the time of release and the first load value 3 standard deviations above the mean magnitude in the 200 ms prior to postural disturbance, with subsequent values increasing.
|Study Start Date:||August 2013|
|Estimated Study Completion Date:||October 2014|
|Estimated Primary Completion Date:||February 2014 (Final data collection date for primary outcome measure)|
|Experimental: Sensory Conditions||
Other: Sensory Intervention
Please refer to this study by its ClinicalTrials.gov identifier: NCT01912794
|Contact: Alessandra R Martinelli, Masteremail@example.com|
|Escola de Educação física e Esporte, Universidade de São Paulo||Not yet recruiting|
|São Paulo, Brazil, 05508-030|
|Contact: Alessandra R Martinelli, Master +55113091-8795 firstname.lastname@example.org|
|Principal Investigator: Alessandra R Martinelli, Master|
|Study Director:||Luis A Teixeira, PhD|