Ventilation Strategy Reduces Postoperative Atelectasis
|ClinicalTrials.gov Identifier: NCT01911923|
Recruitment Status : Withdrawn
First Posted : July 30, 2013
Last Update Posted : August 26, 2014
|Condition or disease||Intervention/treatment||Phase|
|Pulmonary Atelectasis||Procedure: No CPAP/PEEP and 100 % oxygen Procedure: CPAP/PEEP and 30 % oxygen||Not Applicable|
During general anesthesia, the combination of reduced functional residual capacity (FRC), high inspiratory oxygen fraction (FIO2), and airway closure are the main factors implicated in the atelectasis, shunt and shunt-like effects that account for the majority of the impaired oxygenation seen during general anesthesia.
Previous studies have shown that formation of atelectasis during preoxygenation and induction of anesthesia can be avoided by adding a continuous positive airway pressure (CPAP) followed by a positive end-expiratory pressure (PEEP).During emergence from anesthesia, high concentrations of oxygen predispose to atelectasis formation. Even a recruitment maneuver, followed by ventilation with 100% oxygen with a PEEP/CPAP of 10 cm H2O until extubation, failed to improve postoperative oxygenation compared with that achieved with zero end-expiratory pressure (ZEEP).This failure may have been caused by the presence of lung regions with high oxygen concentrations.
The investigators hypothesized that by inducing and discontinuing anesthesia during CPAP/PEEP and deliberately reducing FIO2 after extubation, postoperative atelectasis would be reduced compared with standard protocols. To test our hypothesis, the investigators studied 1) a control group with no CPAP/PEEP and a FIO2 of 1.0 while breathing spontaneously after extubation, and 2) an intervention group that was on CPAP/PEEP of 6 cmH2O from induction to extubation and that received an FIO2 of 1.0 until extubation and then an FIO2 of 0.3 via a facemask while on CPAP after extubation.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||0 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Outcomes Assessor)|
|Official Title:||Reduction in Postoperative Atelectasis by Continuous Positive Airway Pressure and Low Oxygen Concentration After Endotracheal Extubation.|
|Study Start Date :||August 2013|
|Estimated Primary Completion Date :||November 2013|
|Estimated Study Completion Date :||November 2013|
Active Comparator: No CPAP/PEEP and 100 % oxygen
This is the control group
Procedure: No CPAP/PEEP and 100 % oxygen
This is the control group and 100 % oxygen will be used during induction of and emergence from anesthesia, no enhanced level of CPAP/PEEP is implemented. During controlled ventilation ventilation mode is volume controlled.
Experimental: CPAP/PEEP and 30 % oxygen
This is the intervention group
Procedure: CPAP/PEEP and 30 % oxygen
During all phases of anesthesia CPAP/PEEP will be used together with 100 % oxygen during induction of as well during emergence from anesthesia until after extubation when 30 % oxygen will be used.
- Area of atelectasis [ Time Frame: 30 minutes ]The area of atelectasis is investigated by computed tomography of the lungs postoperatively
- Peripheral oxygen saturation (SpO2) [ Time Frame: 2 hours ]SpO2 is assessed immediately after extubation and then continuously postoperatively
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01911923
|Västmanlands sjukhus Köping|
|Köping, Västmanland, Sweden, 721 89|
|Principal Investigator:||Lennart Edmark, Md||Landstinget Vastmaland|