Use of Cardiac-MRI to Predict Results for People With Severe Aortic Stenosis
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|ClinicalTrials.gov Identifier: NCT01905852|
Recruitment Status : Withdrawn
First Posted : July 23, 2013
Last Update Posted : February 14, 2018
- Aortic valve stenosis is a disease that makes a major heart valve get smaller. This reduces heart function and causes death. Severe aortic stenosis (AS) can be treated in a couple of ways, including replacing a heart valve.
Researchers want to study fibrosis in the heart. A sub-study will test whether heart function and blood supply improve after a valve replacement.
- Adults at least 18 years old with aortic stenosis.
- Participants will visit a clinic for 1 day for magnetic resonance imaging (MRI) of their heart. This uses magnets, radio waves, and computers to produce detailed pictures of the heart.
- After this visit, participants will have their aortic valve procedure at the the Washington Hospital Center. A hospital team will contact participants for 1 year by phone or email. This follow-up will consist of 15 minutes of questions about the participant s health status.
- Some participants will join a sub-study.
- They will be given an additional medication to evaluate the blood supply of the heart.
- They will visit a clinic for 1 day for an MRI of their heart, as part of the main study, prior to the aortic valve replacement.
- After they have their valve replaced at the hospital, they will return to the clinic for another MRI.
- They will have the same follow-up as in the main study.
|Condition or disease|
|Aortic Valve Stenosis|
|Study Type :||Observational|
|Actual Enrollment :||0 participants|
|Official Title:||Utilization of Cardiac Magnetic Resonance Imaging to Predict Clinical Outcomes of Patients With Severe Aortic Stenosis|
|Study Start Date :||June 27, 2013|
|Estimated Primary Completion Date :||December 31, 2016|
|Estimated Study Completion Date :||December 31, 2016|
- To assess the ability of cardiac MRI measurement of extracellular volume fraction (related to myocardial fibrosis) to predict short and long term LV function of subjects with severe aortic stenosis undergoing transcatheter AVR. [ Time Frame: 3 years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01905852
|Principal Investigator:||Andrew E Arai, M.D.||National Heart, Lung, and Blood Institute (NHLBI)|