MRI FDG PET Imaging Cervix
|ClinicalTrials.gov Identifier: NCT01899404|
Recruitment Status : Active, not recruiting
First Posted : July 15, 2013
Last Update Posted : December 4, 2017
The standard treatment for cervix cancer at Princess Margaret Hospital is external radiation with chemotherapy followed by internal radiation, called brachytherapy. Currently, brachytherapy treatment is planned on a type of Magnetic Resonance Imaging (MRI) called T2-weighted (T2W) MRI.
The main purpose of this study is to determine whether the following imaging tests can visualize the tumor better for planning the brachytherapy treatment:
- special types of MRI called diffusion weighted MRI (DWI) and dynamic-contrast enhanced MRI (DCE-MRI); and
- an x-ray test called positron emission test (PET) performed with a sugar dye called FDG. MRI-guided brachytherapy is resource-intensive and not widely available.
|Condition or disease||Intervention/treatment||Phase|
|Cervical Cancer Squamous Cell||Biological: 18-FDG PET/CT, DWI, DCE-MRI||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||25 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||A Pilot Prospective Study of the Utility of Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI), Diffusion Weighted MRI (DWI)and Positron Emission Tomography (PET) Imaging With 18F-Fluorodeoxyglucose (18FDG) in Brachytherapy for Cervix Cancer|
|Actual Study Start Date :||October 3, 2012|
|Actual Primary Completion Date :||December 2016|
|Estimated Study Completion Date :||October 2018|
|Experimental: 18-FDG PET/CT, DWI, DCE-MRI||
Biological: 18-FDG PET/CT, DWI, DCE-MRI
All patients on this study will receive a Diffuse Weighted MRI and Dynamic Contrast Enhancing MRI during the routine MRI session on the day of brachytherapy (additional 10 minutes), and a FDG PET/CT scanning session on the day of brachytherapy.
- Target delineation in brachytherapy using standard T2-weighted MRI versus DCE-MRI, DWI and FDG-PET/CT imaging: gross tumor volume and high-risk clinical target volume in patients with cervical cancer [ Time Frame: 2 years ]
- Target delineation using standard MRI acquired during the last week of EBRT fused to planning CT versus full MRI-guided brachytherapy. [ Time Frame: 2 years ]This objective will evaluate the potential for translation of this technique to centres with limited MRI access.
- Follow-up imaging (MRI and 18FDG PET) versus the imaging done at the time of brachytherapy [ Time Frame: 2 years ]
- Imaging techniques for visualizing the brachytherapy applicator. [ Time Frame: 2 years ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01899404
|University Health Network, The Princess Margaret|
|Toronto, Ontario, Canada, M5G 2M9|
|Principal Investigator:||Kathy Han, MD||University Health Network, The Princess Margaret|