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Effects of Motive-Oriented Therapeutic Relationship in the Early-Phase Treatment of Borderline Personality Disorder (MOTR)

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ClinicalTrials.gov Identifier: NCT01896024
Recruitment Status : Completed
First Posted : July 11, 2013
Last Update Posted : December 2, 2014
Sponsor:
Information provided by (Responsible Party):
Ueli Kramer, University of Lausanne Hospitals

Brief Summary:

The present research aims at examining the effectiveness of a specific set of therapist relational interventions and attitudes, called the Motive-Oriented Therapeutic Relationship (MOTR), based on Plan Analysis (Caspar, 2007) in the early-phase treatment of patients diagnosed with Borderline Personality Disorder.

The investigators intend to include N = 80 outpatients diagnosed with Borderline Personality Disorder, consulting at the Outpatient Personality Disorder Program of the Karl Jaspers Clinical Unit, in collaboration with the Institute of Psychotherapy, at the Department of Psychiatry-CHUV, University of Lausanne and in collaboration with the University of Berne, Switzerland. Patients are assigned by chance to two treatment conditions 1) Control condition (General Psychiatric Management; Gunderson & Links, 2008) and 2) MOTR-condition. The investigators hypothesize better results in the MOTR-condition, as compared to the control condition in terms of symptom reduction pre-post.

The conduct of the study represents a significant contribution to the understanding and enhancement of relationship aspects in the treatment of patients diagnosed with Borderline Personality Disorder which may be of potential benefit for these patients.


Condition or disease Intervention/treatment Phase
Borderline Personality Disorder Behavioral: Psychiatric Management Behavioral: Motive-oriented therapeutic relationship/Plan Analysis Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 85 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Treatment
Study Start Date : June 2010
Actual Primary Completion Date : May 2013
Actual Study Completion Date : April 2014

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Active Comparator: General Psychiatric Management (GPM; Gunderson & Links, 2008)
psychodynamic-psychiatric treatment for borderline personality disorder
Behavioral: Psychiatric Management
Experimental: GPM plus Motive-Oriented Therapeutic Relationship
use of Plan Analysis and Motive-oriented therapeutic relationship, as add-on variable to GPM
Behavioral: Psychiatric Management
Behavioral: Motive-oriented therapeutic relationship/Plan Analysis



Primary Outcome Measures :
  1. Outcome Questionnaire -45.2 (Lambert et al., 2004) [ Time Frame: 3 months ]
    pre- post- intervention in a randomized controlle trial; measure of symptom reduction over 3 months


Secondary Outcome Measures :
  1. Inventory of Interpersonal Problems (Horowitz et al., 1988) [ Time Frame: 3 months ]
    Measure of interpersonal problems after 3 months of therapy


Other Outcome Measures:
  1. Borderline Symptom List (Bohus, 2009) [ Time Frame: 3 months ]
    Symptom reduction of borderline symptoms over 3 months of treatment



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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • DSM-IV Borderline Personality Disorder;
  • between 18 and 65 yrs of age

Exclusion Criteria:

  • DSM-IV psychotic disorders,
  • mental retardation,
  • substance abuse in the forefront

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01896024


Locations
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Switzerland
Department of Psychiatry-CHUV, University of Lausanne
Lausanne, VD, Switzerland, 1004
Sponsors and Collaborators
University of Lausanne Hospitals

Publications of Results:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Ueli Kramer, PhD, University of Lausanne Hospitals
ClinicalTrials.gov Identifier: NCT01896024     History of Changes
Other Study ID Numbers: SNSF 100014-134562
First Posted: July 11, 2013    Key Record Dates
Last Update Posted: December 2, 2014
Last Verified: December 2014

Additional relevant MeSH terms:
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Personality Disorders
Borderline Personality Disorder
Mental Disorders