Altitude, Exercise and Glucose Metabolism in Pre-diabetic Men

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01890876
Recruitment Status : Unknown
Verified July 2013 by Martin Burtscher, Universitaet Innsbruck.
Recruitment status was:  Enrolling by invitation
First Posted : July 2, 2013
Last Update Posted : July 8, 2013
Medical University Innsbruck
Information provided by (Responsible Party):
Martin Burtscher, Universitaet Innsbruck

Brief Summary:

Concentric (CE) and eccentric (EE) exercises may differently affect glucose metabolism which may be additionally modified when exercises are performed in hypoxia, e.g. at moderate (1500 - 2500 m) or high (2500 - 3500 m) altitudes. However, data on the effects of glucose metabolism due to CE and EE in hypoxia are scarce but would be of utmost importance considering the increasing number of persons suffering from impaired glucose tolerance or diabetes and the unique opportunities provided by the mountainous regions of the Alps to perform CE (e.g. uphill hiking) and EE (downhill hiking, downhill skiing) at altitude between 1500 - 3500 m. Metabolic responses to exercise may be largely mediated by interleukin 6 (IL-6), which is predominantly derived from the contracting limbs and may support the maintenance of metabolic homeostasis during exercise. In addition, IL-6 is elevated with acute and chronic altitude exposure at least partly mediated via adrenergic stimulation. Thus, the type of exercise as well as hypoxia may contribute to IL-6 elevations and differences in serum IL-6 concentrations might help to explain distinctions between responses of glucose metabolism to CE and EE at low and moderate to high altitude.

32 male subjects suffering from pre-diabetes will be randomly assigned to a downhill (EE) or uphill (CE) walking group performing 9 sessions at low altitude (860 - 1360 m) and 9 sessions at moderate to high altitude (2000 - 2500 m). Between normoxic and hypoxic condition will be a break of approximately 12 month. Measurements of glucose metabolism, IL-6 plasma concentration will be performed pre, mid (day 5) and post intervention. Moreover anthropometric, strength and exercise capacity characteristics will be performed pre and post intervention.

We hypothesize that EE in hypoxia is more effective in the modulation of glycemic control in pre-diabetic men than CE in hypoxia as well as EE and CE in normoxia. It is suggested that effects on glucose metabolism are associated with changes in plasma IL-6 concentrations. EE in hypoxia is expected to result in a more persistent rise of plasma IL-6 concentration than CE in hypoxia and in normoxia and to a more pronounced rise in plasma IL-6 than EE in normoxia.

Condition or disease Intervention/treatment Phase
Diabetes Other: Walking uphill Other: Walking downhill Not Applicable

Detailed Description:
Not desired.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 32 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Altitude-dependent Effects of Concentric and Eccentric Exercise on Glucose Metabolism in Pre-diabetic Men
Study Start Date : June 2013
Estimated Primary Completion Date : December 2014
Estimated Study Completion Date : December 2015

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Active Comparator: Low altitude
Walking uphill Walking downhill
Other: Walking uphill
ascending about 500 m
Other: Walking downhill
descending about 500 m
Active Comparator: High altitude
Walking uphill Walking downhill
Other: Walking uphill
ascending about 500 m
Other: Walking downhill
descending about 500 m

Primary Outcome Measures :
  1. Glucose tolerance [ Time Frame: 18 months ]

Secondary Outcome Measures :
  1. Myokines [ Time Frame: 18 months ]
  2. Cardiovascular fitness [ Time Frame: 18 months ]

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years to 65 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Pre-diabetes
  • male
  • age 50-65 years

Exclusion Criteria:

  • smoking
  • BMI > 30 kg/m2
  • diseases not compatible with intervention

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01890876

Department of Sport Science, Medical Section, University of Innsbruck
Innsbruck, Austria, 6020
Sponsors and Collaborators
Universitaet Innsbruck
Medical University Innsbruck
Principal Investigator: Martin Burtscher, Professor department of sport science, medical section, university innsbruck

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Martin Burtscher, Univ.-Prof. Mag. DDr. Martin Burtscher, Universitaet Innsbruck Identifier: NCT01890876     History of Changes
Other Study ID Numbers: AN5029
First Posted: July 2, 2013    Key Record Dates
Last Update Posted: July 8, 2013
Last Verified: July 2013

Keywords provided by Martin Burtscher, Universitaet Innsbruck:
glucose tolerance, hypoxia, myokines, exercise

Additional relevant MeSH terms:
Prediabetic State
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases