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Imaging of Atherosclerosis With 68Ga-MSA

This study has been completed.
Ministry of Health & Welfare, Korea
Information provided by (Responsible Party):
Hong Seog Seo, Korea University Identifier:
First received: June 26, 2013
Last updated: August 23, 2013
Last verified: August 2013
Despite of intensive efforts, no specific ath¬erosclerosis-targeting agent labeled with positron emitter is not yet available. Fortunately, some scientists made the major advance in the field of clinical atherosclerosis molecular imaging by the metabolic PET reporter agent 18F(fluorine-18)-FDG(Fludeoxyglucose) applied to noninvasively image plaque macrophages in carotid arteries. However, coronary and cerebral arterial segments remain uninterpretable due to metabolic property of 18F-FDG. Applying the character of the terminal mannose residues of MSA binding with the mannose receptors of macrophages in atherosclerosis, we investigate whether 68Ga-MSA can be a novel agent for non-invasive molecular imaging of atherosclerotic lesion in PET.

Atherosclerosis Noninvasive Imaging of Atherosclerosis

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Identification of Vascular Inflammatory Image Using a 68Ga-MSA(Gallium-68 Neomannosyl Human Serum Albumin) in Patients With Atherosclerotic Lesions

Resource links provided by NLM:

Further study details as provided by Hong Seog Seo, Korea University:

Primary Outcome Measures:
  • comparison of SUV(standard uptake unit) at atherosclerotic plaque of aorta and carotid arteries among 3 groups [ Time Frame: 1 day at the time of PET(positron emission tomogram) imaging ]

Secondary Outcome Measures:
  • side effect of PET imaging with 68Ga-MSA [ Time Frame: with 7 days after PET imaging ]
    any side effects including changes of biochemical values and vital signs

Enrollment: 60
Study Start Date: August 2012
Study Completion Date: August 2013
Primary Completion Date: August 2013 (Final data collection date for primary outcome measure)
acute coronary syndrome
patients with acute myocardial infarction and unstable angina
chronic stable angina
patients with chronic stable angina
control subjects without coronary artery disease


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
20 patients with acute coronary syndrome, 20 patients with chronic stable angina and 20 control subjects wihout coronary artery disease of the Cardiovascular Center at Korea University Guro Hospital

Inclusion Criteria:

  • acute coronary syndrome(acute myocardial infarction, unstable angina)
  • chronic stable angina
  • control without coronary artery disease

Exclusion Criteria:

  • pregnancy, allergy to albumin, chronic inflammatory disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT01889693

Korea, Republic of
Korea University Guro Hospital
Seoul, Korea, Republic of, 152-703
Sponsors and Collaborators
Korea University
Ministry of Health & Welfare, Korea
  More Information

Responsible Party: Hong Seog Seo, Professor of Medicine, Korea University Identifier: NCT01889693     History of Changes
Other Study ID Numbers: GaMSA-Atherosclerosis
Study First Received: June 26, 2013
Last Updated: August 23, 2013

Keywords provided by Hong Seog Seo, Korea University:
positron emission tomography
neomannosyl human serum albumin

Additional relevant MeSH terms:
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases processed this record on July 24, 2017