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Obesity and Mortality

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ClinicalTrials.gov Identifier: NCT01889225
Recruitment Status : Completed
First Posted : June 28, 2013
Last Update Posted : August 25, 2014
Sponsor:
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by (Responsible Party):
David Allison, Phd, University of Alabama at Birmingham

Brief Summary:
Previous analyses of the National Health and Nutrition Examination Survey have suggested that the mortality rate associated with obesity has decreased over calendar time in the U.S. population, potentially due to improvements in the medical care of obesity and its associated diseases. The primary aim of this project is to evaluate whether this reduction in the detrimental association of obesity with mortality rate over calendar time is supported by other data from U.S. prospective studies.

Condition or disease
Obesity and Overweight

Study Type : Observational
Actual Enrollment : 311982 participants
Observational Model: Cohort
Time Perspective: Prospective
Study Start Date : January 2008
Actual Primary Completion Date : December 2013
Actual Study Completion Date : December 2013

Group/Cohort
Multiple Risk Factor Intervention Trial - Usual Group
Multiple Risk Factor Intervention Trial - Referred Group
Framingham Heart study
Framingham Offspring cohort
Atherosclerosis Risk In Communities
Charleston Heart study
Cardiovascular Health study
Rancho Bernardo study
Nurses' Health I study
Panel Study Income Dynamics
MRFIT Referred Care
HDFP Referral Care
Alameda County Health and Ways of Living Study
Nurses' Health II study
Tecumseh County Health study
EPESE-East Boston
Established Populations for Epidemiologic Studies of the Elderly-East Boston
EPESE-Duke
Established Populations for Epidemiologic Studies of the Elderly-Duke
EPESE-Iowa
Established Populations for Epidemiologic Studies of the Elderly-Iowa
EPESE-New Haven
Established Populations for Epidemiologic Studies of the Elderly-New Haven



Primary Outcome Measures :
  1. Change in Years of Life Lost Associated with Standard BMI categories Over Calendar Time [ Time Frame: Between 1960 and 2000 (up to 40 years) ]

Secondary Outcome Measures :
  1. Change in Adjusted Hazard Ratio Over Calendar Time for Standard BMI Categories [ Time Frame: Between 1960 and 2000 (up to 40 years) ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
U.S. based prospective cohorts of adults
Criteria

Inclusion Criteria:

  • U.S. based studies with at least 1500 subjects
  • At least 5 years of mortality follow-up
  • BMI measured or self-reported available at 2 or more separate calendar time
  • Subjects varied in age at baseline

Exclusion Criteria:

  • Any study that does not meet the inclusion criteria was excluded

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01889225


Sponsors and Collaborators
University of Alabama at Birmingham
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Investigators
Principal Investigator: David B Allison, Ph.D. University of Alabama at Birmingham

Responsible Party: David Allison, Phd, Principal Investigator, University of Alabama at Birmingham
ClinicalTrials.gov Identifier: NCT01889225     History of Changes
Other Study ID Numbers: R01-DK076771-Aim1A
R01DK076771 ( U.S. NIH Grant/Contract )
First Posted: June 28, 2013    Key Record Dates
Last Update Posted: August 25, 2014
Last Verified: August 2014

Additional relevant MeSH terms:
Obesity
Overweight
Overnutrition
Nutrition Disorders
Body Weight
Signs and Symptoms