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Trial record 10 of 6677 for:    senior citizens

Influence of tDCS on Cortical Plasticity in Healthy Older Adults

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ClinicalTrials.gov Identifier: NCT01888055
Recruitment Status : Unknown
Verified December 2016 by Agnes Flöel, Charite University, Berlin, Germany.
Recruitment status was:  Active, not recruiting
First Posted : June 27, 2013
Last Update Posted : December 22, 2016
Sponsor:
Information provided by (Responsible Party):
Agnes Flöel, Charite University, Berlin, Germany

Brief Summary:
The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).

Condition or disease Intervention/treatment Phase
Healthy Older Adults Device: transcranial direct current stimulation Device: sham stimulation Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 15 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Influence of Transcranial Direct-current Stimulation on Cortical Plasticity in Healthy Older Adults
Study Start Date : May 2013
Estimated Primary Completion Date : October 2017
Estimated Study Completion Date : December 2017

Arm Intervention/treatment
Experimental: transcranial direct current stimulation Device: transcranial direct current stimulation
Placebo Comparator: sham stimulation Device: sham stimulation



Primary Outcome Measures :
  1. anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults [ Time Frame: 1 week ]
    to investigate whether the anodal transcranial direct current stimulation over the primary motor cortex (M1) in healthy older adults increases cortical plasticity (measured via motor evoked potentials)compared to sham stimulation


Secondary Outcome Measures :
  1. Comparison of tDCS-induced changes on central cholinergic activity [ Time Frame: 1 week ]
    to investigate weather anodal transcranial direct-current stimulation affect central cholinergic activity (measured via a TMS-protocol) in healthy older adults compared to sham stimulation

  2. Comparison of tDCS-induced changes in the learning success [ Time Frame: 1 week ]
    tDCS-induced changes on learning success (performance in a motor learning paradigm in healthy older adults after tDCS vs. sham)

  3. MR elastography [ Time Frame: 1 week ]
    Comparison of viscoelastic parameters in cerebral MR elastography in healthy older adults

  4. genetic polymorphism, ApoE4 [ Time Frame: once ]
    optional assessment of genetic Apo4 epsilon status for assessment of differences in cortical plasticity and elasticity between Apo4 epsilon positive and negative participants



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Ages Eligible for Study:   50 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • right-handed according to the Oldfield Händigkeits inventory (lateralization index >70)(1971)
  • no obvious cognitive impairment (MMSE>26, Demtect>13)
  • age between 50 and 80 years

Exclusion Criteria:

  • Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected
  • Epilepsy, epileptic seizure in medical history
  • Cognitive deficit (MMSE <20)
  • Depressive episode (Beck Depression Inventory (BDI) > 12)
  • intake of centrally active drugs <3 months , particularly acetylcholinesterase inhibitors
  • Pregnancy
  • Pacemaker (contraindication for MRI)
  • Other metal parts in the body (contraindication for MRI)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01888055


Locations
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Germany
Klinik und Poliklinik für Neurologie, Charité Universitätsmedizin Berlin
Berlin, Germany, 10117
Sponsors and Collaborators
Charite University, Berlin, Germany

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Responsible Party: Agnes Flöel, Prof. Dr., Charite University, Berlin, Germany
ClinicalTrials.gov Identifier: NCT01888055     History of Changes
Other Study ID Numbers: Plasticity in healthy adults
First Posted: June 27, 2013    Key Record Dates
Last Update Posted: December 22, 2016
Last Verified: December 2016

Keywords provided by Agnes Flöel, Charite University, Berlin, Germany:
Healthy older adults Cortical Plasticity
Transcranial Direct Current Stimulation