Influence of tDCS on Cortical Plasticity in Patients With Mild Cognitive Impairment (MCI)
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The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in patients with mild cognitive impairment (MCI) leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).
Condition or disease
Patients With Mild Cognitive Impairment
Device: transcranial direct current stimulationDevice: sham stimulation
the anodal transcranial direct current stimulation over the primary motor cortex (M1) in patients with mild cognitive impairment (MCI) [ Time Frame: 1 week ]
to investigate whether the anodal transcranial direct current stimulation over the primary motor cortex (M1) in patients with mild cognitive impairment (MCI) increases cortical plasticity (measured via motor evoked potentials) compared to sham stimulation
Secondary Outcome Measures
Comparison of tDCS-induced changes on central cholinergic activity [ Time Frame: 1 week ]
to investigate weather the anodal transcranial direct current stimulation affect central cholinergic activity (measured via a TMS protocol) in MCI patients compared to sham stimulation
Comparison of tDCS-induced changes in learning success [ Time Frame: 1 week ]
tDCS-induced changes in learning success (performance in a motor learning paradigm in patients with MCI after tDCS vs. sham stimulation)
MR elastography [ Time Frame: 1 week ]
Comparison of viscoelastic parameters in cerebral MR elastography in patients with MCI
genetic polymorphism, ApoE4 [ Time Frame: once ]
optional assessment of genetic Apo4 epsilon status for assessment of differences in cortical plasticity and elasticity between Apo4 epsilon positive and negative participants
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Ages Eligible for Study:
50 Years to 80 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Right-handed according to the Oldfield Händigkeits inventory (lateralization index> 70) (1971)
Cognitive impairment according to the diagnostic criteria of a MCI (amnesic or even multiple domains)
No therapeutic treatment with AChE inhibitors
No motor impairments relevant to everyday life
Age 50 to 80 years
Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected