Computational Modeling for Prediction of Acoustic Changes in Vowel Production Due to Orthognathic Surgery (PUMA)
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ClinicalTrials.gov Identifier: NCT01887977 |
Recruitment Status
: Unknown
Verified June 2013 by Turku University Hospital.
Recruitment status was: Recruiting
First Posted
: June 27, 2013
Last Update Posted
: June 27, 2013
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Condition or disease | Intervention/treatment | Phase |
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Jaw Deformity Facial Asymmetry | Other: MRI examination | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 20 participants |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Official Title: | Computational Modeling for Prediction of Acoustic Changes in Vowel Production |
Study Start Date : | March 2012 |
Estimated Primary Completion Date : | December 2013 |
Estimated Study Completion Date : | December 2014 |
Arm | Intervention/treatment |
---|---|
Experimental: Computational modeling |
Other: MRI examination
The vocal and nasal tracts from the lips and nostrils to the beginning of the trachea are imaged with Siemens Avanto 1.5T MRI machine using carefully optimized, externally triggered imaging sequences that are synchronized with the rest of the experimental setting. A sound sample, given by the test subject, is recorded simultaneously to obtain a coupled data set: the speech sound and the precise anatomy which produces it.
Other Name: with Siemens Avanto 1.5T MRI machine
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- Acoustic changes in vowel production of hte patients duoe to orthognathic surgery [ Time Frame: 6 and 30 weeks postoperatively ]a measurement of sound formants
- Anatomical changes in vocal tract due to orthognathic surgery [ Time Frame: 6 and 30 weeks postoperatively ]changes in vocal track dimensions

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Ages Eligible for Study: | 18 Years to 50 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Healthy patients undergoing orthognathic surgery
Exclusion Criteria:
- Patients with conditions in which MRI examination is contraindicated (e.g. pace maker)
- Patients who require several operations or segmented jaw surgery
- Patients with cognitive impairment
- Patients with numerous dental amalgam fillings that may cause artifacts in MR images

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01887977
Finland | |
Turku University Hospital | Recruiting |
Turku, Finland, F!-20521 Turku | |
Contact: Risto P Happonen, Professor +358-50-4121477 risto-pekka.happonen@tyks.fi |
Principal Investigator: | Risto P Happonen, Professor | Turku University Hospital, Po. Box 52, FI-20521 Turku, Finland |
Responsible Party: | Turku University Hospital |
ClinicalTrials.gov Identifier: | NCT01887977 History of Changes |
Other Study ID Numbers: |
T17/2012 |
First Posted: | June 27, 2013 Key Record Dates |
Last Update Posted: | June 27, 2013 |
Last Verified: | June 2013 |
Keywords provided by Turku University Hospital:
Orthognathic surgery Speech production MRI |
Additional relevant MeSH terms:
Facial Asymmetry Jaw Abnormalities Pathological Conditions, Anatomical Jaw Diseases Musculoskeletal Diseases Maxillofacial Abnormalities |
Craniofacial Abnormalities Musculoskeletal Abnormalities Stomatognathic Diseases Stomatognathic System Abnormalities Congenital Abnormalities |