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Effect of Time Shift of Transcranial Direct Current Stimulation (tDCS) for Treatment of Acute Tinnitus

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2013 by University Hospital, Antwerp.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
Ethisch Comité UZ Antwerpen, University Hospital, Antwerp Identifier:
First received: June 21, 2013
Last updated: June 25, 2013
Last verified: June 2013

The treatment for patients with acute tinnitus consists of Methylprednisolone and hyperbaric oxygen therapy. For this study transcranial direct current stimulation (tDCS) was added to the protocol. The purpose is to determine the effect of the time shift of tDCS. Two conditions will be compared: tDCS simultaneously with the hyperbaric oxygen therapy or tDCS 3 weeks after the start of the tinnitus.

An audiological testing will be performed at the day of admission, after 3 weeks, 6 weeks and 12 weeks.

Condition Intervention
Other: transcranial direct current stimulation (tDCS)

Study Type: Interventional
Study Design: Allocation: Randomized
Masking: Open Label

Resource links provided by NLM:

Further study details as provided by University Hospital, Antwerp:

Primary Outcome Measures:
  • Improvement of tinnitus [ Time Frame: 12 weeks ]
    Tinnitus Questionnaire, Visual Analog Scale, Beck Depression Index, Hyperacusis questionnaire

Secondary Outcome Measures:
  • Hearing [ Time Frame: 12 weeks ]
    Audiometry, Otoacoustic emissions, Tympanometry, Speech in noise

Study Start Date: April 2012
Estimated Primary Completion Date: April 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: tDCS simultaneously with hyperbaric oxygen therapy Other: transcranial direct current stimulation (tDCS)
Active Comparator: tDCS 3 weeks after start tinnitus Other: transcranial direct current stimulation (tDCS)


Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • age between 18 and 50 years
  • presence of acute tinnitus or worsening of tinnitus caused by otogenic disease
  • registration in UZA within 48 hours after start tinnitus
  • VAS-score ≥ 4
  • ability to understand and sign informed consent

Exclusion Criteria:

  • history of epileptic seizures
  • severe organic comorbidity
  • psychiatric disorders or a history of psychiatric disorders with psychotic symptoms
  • Pace maker
  • pregnancy
  Contacts and Locations
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Please refer to this study by its identifier: NCT01886729

Contact: Sarah Rabau 003238215235

University hospital of Antwerp Recruiting
Edegem, Antwerp, Belgium, 2650
Contact: Sarah Rabau    003238215235   
Sponsors and Collaborators
University Hospital, Antwerp
  More Information

Responsible Party: Ethisch Comité UZ Antwerpen, Sarah Rabau, University Hospital, Antwerp Identifier: NCT01886729     History of Changes
Other Study ID Numbers: EC 11/18/146
Study First Received: June 21, 2013
Last Updated: June 25, 2013

Keywords provided by University Hospital, Antwerp:
transcranial direct current stimulation
time shift

Additional relevant MeSH terms:
Hearing Disorders
Ear Diseases
Otorhinolaryngologic Diseases
Sensation Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on May 22, 2017