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RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT01885299
Recruitment Status : Recruiting
First Posted : June 24, 2013
Last Update Posted : July 21, 2021
Information provided by (Responsible Party):
The Radiosurgery Society

Brief Summary:
The RSSearch® Registry is an international multi-year database designed to track SRS/SBRT (Stereotactic Radiosurgery/Stereotactic Body Radiation Therapy) utilization, treatment practices and outcomes to help determine, over time, the most effective use of these systems in management of patients with life threatening tumors and other diseases. (This study was formally called ReCKord and included the CyberKnife only; The ReCKord study continues as a CyberKnife subset of RSSearch.)

Condition or disease Intervention/treatment
Neoplasms Arteriovenous Malformation of Central Nervous System Trigeminal Neuralgia Radiation: SRS/SBRT

Detailed Description:

The Registry is designed to help SRS/SBRT (Stereotactic Radiosurgery/Stereotactic Body Radiation Therapy) users to understand utilization of and key treatment outcomes for these treatment approaches. Some of the objectives include:

Allow participants to record information about usage of SRS/SBRT in everyday practice, including patient characteristics and disease information, treatment plans and outcomes Provide participants with ready access to data for publication of their own experience and as a tool for establishing collaborations with other participating sites Facilitate quality improvement efforts for individual treatment providers Understand the effectiveness of different treatment plans for different types of lesions, diseases and treatments

The Registry tracks select outcomes for each condition treated by SRS/SBRT (for example, PSA for prostate cancer); the Registry also provides individual participants the ability to add additional outcomes for each and any condition of specific interest to their institutions.

The Registry is hosted by Vision Tree, Inc who is an independent vendor of electronic registries; they are responsible for HIPAA compliance, including all security mechanisms.

Patients will be enrolled prospectively. Some retrospective patient data is likely to be included in order to capture both short and longer term outcomes data.

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Study Type : Observational [Patient Registry]
Estimated Enrollment : 50000 participants
Observational Model: Cohort
Time Perspective: Other
Target Follow-Up Duration: 20 Years
Official Title: Multi-Institution Registry of SRS/SBRT Procedures
Study Start Date : March 2012
Estimated Primary Completion Date : December 2025
Estimated Study Completion Date : December 2025

Resource links provided by the National Library of Medicine

Group/Cohort Intervention/treatment
Patients being treated by SRS/SBRT
Patients with a condition being considered for treatment by SRS/SBRT
Radiation: SRS/SBRT
Intervention varies by condition being treated.

Primary Outcome Measures :
  1. Overall survival [ Time Frame: Up to 5 years ]
    Survival from time of treatment to death

Secondary Outcome Measures :
  1. Local and distant recurrence [ Time Frame: One to Five years ]
    Calculated from time of treatment to recurrence

Other Outcome Measures:
  1. Treatment toxicity [ Time Frame: Immediate -5 years ]
    Complications of treatment. These complications are organ specific depending on which organ is being treated. For example, if the prostate is being treated,there may be rectal and urinary complications. If the brain is being treated, there may be headaches or nausea. The Radiation Therapy Oncology Group (RTOG) scale used for defining and measuring complications of radiotherapy is incorporated into the Registry database.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Any patients who have a SRS/SBRT procedure

Inclusion Criteria:

  • Diagnosis of benign or malignant tumors or other conditions deemed treatable by stereotactic radiosurgery or stereotactic body radiotherapy
  • Willingness to sign an Informed Consent Document or verbally agree to participation

Exclusion Criteria:

  • There are no specific exclusion criteria, but patients who are unwilling to sign the ICD or who decline participation will not be included

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01885299

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Contact: Jan Jenkins, RN
Contact: Joanne Davis, PHD

Show Show 25 study locations
Sponsors and Collaborators
The Radiosurgery Society
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Study Director: Anand Mahadevan, MD The Radiosurgery Society
Additional Information:


Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: The Radiosurgery Society Identifier: NCT01885299    
Obsolete Identifiers: NCT01563549
Other Study ID Numbers: RSSearch Patient Registry
First Posted: June 24, 2013    Key Record Dates
Last Update Posted: July 21, 2021
Last Verified: July 2021
Keywords provided by The Radiosurgery Society:
Benign tumors
Malignant tumors
Cranial tumors
Extracranial tumors
Stereotactic radiosurgery
Stereotactic body radiotherapy
Additional relevant MeSH terms:
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Trigeminal Neuralgia
Arteriovenous Malformations
Peripheral Nervous System Diseases
Neuromuscular Diseases
Nervous System Diseases
Neurologic Manifestations
Congenital Abnormalities
Vascular Malformations
Cardiovascular Abnormalities
Cardiovascular Diseases
Vascular Diseases
Trigeminal Nerve Diseases
Facial Neuralgia
Facial Nerve Diseases
Mouth Diseases
Stomatognathic Diseases
Cranial Nerve Diseases