Silent Ureteral Stone: Impact on Renal Function and Kidney Anatomy
Ureteral stones may be silent in 5.3% of patients. The goal of this study was to prospectively evaluate the impact of a silent ureteral stone on renal function.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||The Impact of Silent Ureteral Stone on Renal Function and Kidney Anatomy: a Prospective Analysis|
- Ipsilateral Renal Function [ Time Frame: 1 year ] [ Designated as safety issue: No ]Ipsilateral renal function determined by dimercaptosuccinic acid scintigraphy (DMSA) 12 months after surgery.
- Serum Creatinine level [ Time Frame: 1 year ] [ Designated as safety issue: No ]Serum Creatinine level
- Estimated Creatinine Clearance [ Time Frame: 1 year ] [ Designated as safety issue: No ]Estimated Creatinine Clearance
- Renal Anatomy assessed by Ultrasound [ Time Frame: 1 year ] [ Designated as safety issue: No ]Renal Anatomy assessed by Ultrasound
|Study Start Date:||November 2012|
|Estimated Study Completion Date:||August 2015|
|Estimated Primary Completion Date:||July 2015 (Final data collection date for primary outcome measure)|
Silent Ureteral Stone - Surgical Treatment
Procedure: Surgical Treatment
Surgical Treatment - open, endoscopic or laparoscopic
Other Name: Surgical Treatment - open, endoscopic or laparoscopic
The prevalence of nephrolithiasis is increasing worldwide, reaching 5.2% in North America and 10.1% in Italy. The widespread use of computed tomography and ultrasonography have resulted in a greater detection rate of asymptomatic stones and, in part, might explain the trend. Clinically, kidney or ureteral stones range in severity from asymptomatic to presenting with complete renal failure. Therefore, it is not only the alarming incidence of urinary stone disease, but also the associated burden that makes this one of the most concerning conditions in public health.
The situation becomes even more distressing when managing asymptomatic stones. Studies of the natural history of stones have revealed that only 20% of patients yearly actually become symptomatic from a new stone, and one half of those require surgical intervention at some point. The guidelines are well established for the treatment of symptomatic urolithiasis, and many investigators have extensively studied the management of silent kidney stones. Conversely, the same is not true for silent ureterolithiasis. The purpose of the present study is to report the investigators experience managing silent ureteral stones and to prospectively analyze their true influence on renal function.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01884870
|Contact: Giovanni S Marchini, MD||55-11-98179-8186 ext -||firstname.lastname@example.org|
|Clinics Hospital - University of Sao Paulo Medical School||Recruiting|
|Sao Paulo, SP, Brazil, 05403-000|
|Contact: Eduardo Mazzucchi, PhD 55-11-26618080 ext - email@example.com|
|Principal Investigator: Giovanni S Marchini, MD|
|Sub-Investigator: Eduardo Mazzucchi, PhD|
|Principal Investigator:||Giovanni S Marchini, MD||University of Sao Paulo|