Copeptin in Childhood Epilepsy (EpiCop)
|Study Design:||Time Perspective: Prospective|
|Official Title:||Prospective Study on Copeptin in Childhood Epilepsy|
- Copeptin concentration in serum [ Time Frame: at admission ] [ Designated as safety issue: No ]
- base excess in blood gas analysis [ Time Frame: at admission ] [ Designated as safety issue: No ]
- prolactin [ Time Frame: at admission ] [ Designated as safety issue: No ]
- duration of seizures [ Time Frame: at admission ] [ Designated as safety issue: No ]
- Short term relapse of seizures [ Time Frame: 24 hours after first presentation ] [ Designated as safety issue: No ]
- sodium concentration [ Time Frame: at admission ] [ Designated as safety issue: No ]
- osmolality [ Time Frame: at admission ] [ Designated as safety issue: No ]
- hydrogen ion activity in blood gas analysis [ Time Frame: at admission ] [ Designated as safety issue: No ]hydrogen ion activity = pH
- number of repeated events of seizures [ Time Frame: 12 month ] [ Designated as safety issue: No ]relapse of seizures within 12 month
Biospecimen Retention: Samples Without DNA
|Study Start Date:||April 2013|
|Estimated Study Completion Date:||December 2016|
|Estimated Primary Completion Date:||June 2016 (Final data collection date for primary outcome measure)|
All kind of epilepsy, including febrile seizures
children without seizures at presentation in the emergency but fever due to banal infections
Copeptin is a surrogate marker of the pituitary-secreted nonapeptide arginine-vasopressin (AVP) and has gradually replaced AVP in several clinical studies largely due to its structural and methodological advantages. Copeptin is a marker of non-specific stress response, and has been suggested to have clinical implications in a variety of cardiovascular and non-cardiovascular conditions. However, up to now there are no data available on copeptin in seizure disorders, neither in adults nor in children.
- Circulating copeptin concentrations are increased after generalized seizures, including FS.
- Copeptin is predictive for complexity and relapse in FS.
- to determine copeptin concentrations in children below six years after generalized seizures, either unrelated or related to fever (FS), and in control children below six years without seizures.
- to compare copeptin concentrations with blood-gas parameters (including hydrogen ion concentration (pH), base deficiency, and carbon dioxide), lactate, sodium, chloride, C reactive protein (CRP), and prolactin.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01884766
|Contact: Sven Wellmann, MDemail@example.com|
|Contact: Benjamin Stoecklin, MD|
|University Children's Hospital Basel||Recruiting|
|Basel, Switzerland, 4056|
|Contact: Benjamin Stoecklin, MD firstname.lastname@example.org|
|Sub-Investigator: Benjamin Stoecklin, MD|
|Principal Investigator:||Sven Wellmann, MD||University Children's Hospital Basel, 4056 Basel, Switzerland|