Working… Menu

Fetuin A in Hashimoto Thyroiditis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01884649
Recruitment Status : Completed
First Posted : June 24, 2013
Last Update Posted : June 24, 2013
Information provided by (Responsible Party):
Sevilay Muratli, Istanbul Medeniyet University

Brief Summary:
Fetuin-A levels are reported to be low as a negative acute phase reactant in systemical inflammatory situations. Hashimoto thyroiditis is characterized with inflammation. In this study, we hypothesised that the serum fetuin A levels could be found to be low due to inflammation in patients with Hashimoto thyroiditis

Condition or disease
Hashimoto Thyroiditis

Detailed Description:

Patients ≥ 20 years of age being followed up at the outpatient clinics of the Internal Medicine Department in Medeniyet University Goztepe Training and Research Hospital and fulfilling the eligibility criteria will be included in the study. Approval of the local ethics committee and informed consent of the participants will be received for the study. The study is conducted in accordance with the Declaration of Helsinki. Demographic characteristics, concomitant diseases, smoking and alcohol drinking habits, concomitant medication usage, anthropometric and biochemistry data of the eligible patients will be recorded. Patient group will consist of patients with newly diagnosed Hashimoto thyroiditis and the control group will consist of healthy volunteers.

Groups will be compared according to their demographic, an¬thropometric and biochemistry data and serum fetuin-A levels. In order to detect the relationship between the serum fetuin-A levels and clinical features, correlation analyses will be done.

Layout table for study information
Study Type : Observational [Patient Registry]
Actual Enrollment : 97 participants
Time Perspective: Cross-Sectional
Target Follow-Up Duration: 1 Day
Official Title: Fetuin A as a New Marker of Inflammation in Hashimoto Thyroiditis
Study Start Date : May 2012
Actual Primary Completion Date : October 2012
Actual Study Completion Date : October 2012

Resource links provided by the National Library of Medicine

Group of Hashimoto thyroiditis patients
Healty control group

Primary Outcome Measures :
  1. Comparison of serum fetuin A levels between patients with Hashimoto thyroiditis and healthy subjects [ Time Frame: 1 day (The blood samples were obtained on the same day participants arrived to outpatient clinics.) ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   20 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients ≥ 20 years of age being followed up at the outpatient clinics of the Internal Medicine Department in Medeniyet University Goztepe Training and Research Hospital and fulfilling the below mentioned criteria were included in the study

Inclusion Criteria:

  • patients newly diagnosed with Hashimoto thyroiditis

Exclusion Criteria:

  • Acute infection
  • Acute or chronic inflammatory disease
  • Anti-inflammatory treatment (non-steroidal anti-inflammatory, corticosteroids etc.)
  • Hypoxic situations (chronic obstructive pulmonary disease etc.)
  • Severe heart, kidney and liver disease
  • Pregnancy
  • Endocrine disorders
  • Malignancy
  • Usage of drug that affects thyroid hormone levels
Additional Information:

Layout table for additonal information
Responsible Party: Sevilay Muratli, M.D., Istanbul Medeniyet University Identifier: NCT01884649    
Other Study ID Numbers: GEAH-1
First Posted: June 24, 2013    Key Record Dates
Last Update Posted: June 24, 2013
Last Verified: June 2013
Keywords provided by Sevilay Muratli, Istanbul Medeniyet University:
Acute phase reactant, fetuin A, Hashimoto thyroiditis
Additional relevant MeSH terms:
Layout table for MeSH terms
Hashimoto Disease
Thyroid Diseases
Endocrine System Diseases
Thyroiditis, Autoimmune