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Exercise-induced Hypoalgesia After Comparative Forms of Exercise

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01883895
First Posted: June 21, 2013
Last Update Posted: July 24, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University of Wisconsin, Madison
  Purpose
The study involves recording response to discomfort following different forms of exercise. We think that there will be a increased pain tolerance following exercise but are unsure if there will be a difference between exercises.

Condition Intervention
Pain Device: Forgionei-Barber pressure-pain stimulator Other: Concentric Exercise Other: isometric exercise

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Intervention Model Description:
three treatment design, all participants will perform two exercise sessions (isometric exercise, concentric exercise), as well as a control session in a randomized manner. (This is not a cross-over design as each participant will have their own randomized order of sessions of exercise & control sessions.)
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Exercise-induced Hypoalgesia After Comparative Forms of Anaerobic Training in Healthy Adults

Resource links provided by NLM:


Further study details as provided by University of Wisconsin, Madison:

Primary Outcome Measures:
  • Change in Pain Intensity Ratings (0-100 Pain Scale) [ Time Frame: Average pain rating over 120 seconds ]

    Subjects will rate pain intensity using a 0 (no pain) to 100 (most intense pain imaginable) pain rating scale before and after application of a validated pressure stimulator immediately prior to, and after exercise.

    Ratings will be recorded at 20 second intervals following each administration of the pressure stimulator for a total of 120 seconds. The ratings will then be averaged over all the time points.



Secondary Outcome Measures:
  • Pain Threshold [ Time Frame: We will monitor the subject's reported pain thresholds during the two minute interval that the pressure stimulus is applied. Expected average is less than one minute. ]
    Subjects will press a button attached to a timer out of view of the subject when the pressure stimulus first becomes painful. This will utilize a protocol recognized as a validated measurement of pain threshold.


Enrollment: 34
Study Start Date: June 2013
Study Completion Date: May 2014
Primary Completion Date: May 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
exercise treatment

Concentric exercise: subject will utilize a dumbbell with elbow flexion exercise.

Isometric exercise: Subjects will perform 5 sets of sustained muscle contraction.

Control: Subjects will undergo a control arm where they will rest for approximately 10 minutes.

Pain testing conducted by Forgionei-Barber pressure pain-stimulator for both the control and exercise treatments.

Device: Forgionei-Barber pressure-pain stimulator
Pain testing will be conducted using a Forgioni-Barber pressure-pain stimulator to deliver 3000-gm force to the middle digit of the non-dominant middle finger for up to 120 seconds. During stimulation, subjects will press a button attached to a timer when the pressure stimulus first becomes painful (pain threshold) and will also rate their perceived pain intensity using a 0-100 numeric pain rating scale at 20 second intervals during the 2 minute exposure to the pressure stimulus. This validated protocol has been used in previous research by investigators in this study. This will be used for both exercise sessions and the control session. Forgionei-Barber pressure-pain stimulator will be used.
Other: Concentric Exercise
Concentric testing will utilize a dumbbell with elbow flexion exercise. Subjects will perform 5 sets of 20 reps at 30% MVC. Pain testing will be conducted using a Forgionei-Barber pressure-pain stimulator immediately before and after the exercise.
Other: isometric exercise
When undergoing isometric exercise, subjects will perform 5 sets of sustained muscle contraction for 65 seconds using a hand-grip dynamometer. Pain testing will be conducted using a Forgionei-Barber pressure-pain stimulator immediately before and after the exercise.

  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • normotensive
  • age range 18 to 40 years

Exclusion Criteria:

  • currently taking prescription medications
  • current use of tobacco or recreational drugs including opiates and/or marijuana
  • any chronic illness such as diabetes, cancer, fibromyalgia, or hypertension
  • upper limb musculoskeletal pain, injury, or surgery that will limit ability to exercise
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01883895


Locations
United States, Wisconsin
University of Wisconsin Hospitals and Clinics
Madison, Wisconsin, United States, 53705
Sponsors and Collaborators
University of Wisconsin, Madison
Investigators
Principal Investigator: Nalini Sehgal, MD University of Wisconsin Dept Ortho/Rehab
Study Director: ben rawson, DO University of Wisconsin Dept Ortho/Rehab
  More Information

Responsible Party: University of Wisconsin, Madison
ClinicalTrials.gov Identifier: NCT01883895     History of Changes
Other Study ID Numbers: 2012-0805
First Submitted: June 12, 2013
First Posted: June 21, 2013
Results First Submitted: May 15, 2017
Results First Posted: July 24, 2017
Last Update Posted: July 24, 2017
Last Verified: June 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Plan Description: There is no plan to share the IPD with any other researchers.

Keywords provided by University of Wisconsin, Madison:
Pain
exercise-induced hypoalgesia