Mechanisms of Diabetic Kidney Disease in American Indians
- An ongoing study is looking at American Indians who have kidney problems caused by type 2 diabetes. Kidney disease due to type 2 diabetes is a major problem in American Indians. We previously found that early treatment of kidney disease with losartan was probably beneficial for reducing progression of the disease. Researchers now want to see if these benefits continue to be seen several years after the end of the treatment study.
- To study long-term benefit of losartan treatment for diabetic kidney disease in American Indians with type 2 diabetes.
- Participants in the American Indian diabetic kidney disease study (OH95-DK-N037).
- Participants will have a physical exam and medical history before starting the study. Blood and urine samples will be collected.
- Participants will have a set of tests as part of this study. Those who have severe kidney problems, such as kidney failure, will only have a basic kidney exam with scans. The remaining participants will have a full urine collection and analysis. They will also provide a kidney biopsy.
- Treatment will not be provided as part of this study.
Diabetic Kidney Disease
Diabetes Mellitus, Type 2
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Determinants of Diabetic Nephropathy in American Indians|
- End-Stage Renal Disease [ Time Frame: On-going ]
- Diabetic Neuropathy [ Time Frame: On-going ]
- Diabetic Retinopathy [ Time Frame: On-going ]
|Study Start Date:||May 21, 2013|
|Estimated Study Completion Date:||January 25, 2035|
|Estimated Primary Completion Date:||December 31, 2022 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01878045
|United States, Arizona|
|Phoenix, Arizona, United States, 85014|
|Principal Investigator:||Robert G Nelson, M.D.||National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|