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Trial record 85 of 401 for:    PYY

Oral Glucose Stimulation in Normal-weight and Obese Volunteers

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01875575
Recruitment Status : Completed
First Posted : June 12, 2013
Last Update Posted : June 12, 2013
Sponsor:
Information provided by (Responsible Party):
University Hospital, Basel, Switzerland

Brief Summary:
The objective of this study is to examine gastric emptying and satiety hormones after oral glucose stimulation in 2 different concentrations in normal-weight and obese patients.

Condition or disease Intervention/treatment Phase
Endocrine System Diseases Dietary Supplement: Placebo Dietary Supplement: Glucose 25g Dietary Supplement: Glucose 10g Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 24 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Prevention
Official Title: Oral Glucose in Normal-weight and Obese Volunteers
Study Start Date : February 2013
Actual Primary Completion Date : April 2013
Actual Study Completion Date : April 2013

Resource links provided by the National Library of Medicine

Drug Information available for: Dextrose

Arm Intervention/treatment
Active Comparator: Glucose 10g
10g Glucose in 200ml tap water given orally (plus 50 mg 13C-sodium acetate)via nasogastric tube
Dietary Supplement: Glucose 10g
Active Comparator: Glucose 25g
25g Glucose in 200ml tap water given orally (plus 50 mg 13C-sodium acetate)via nasogastric tube
Dietary Supplement: Glucose 25g
Placebo Comparator: Placebo
intragastric tap water
Dietary Supplement: Placebo



Primary Outcome Measures :
  1. Effect of different oral glucose loads on secretion of satiation hormones [ Time Frame: 240min. ]
    Plasma concentrations of glucose, insulin, glucagon, ghrelin, GLP-1, PYY and CCK are measured


Secondary Outcome Measures :
  1. Effect of different oral glucose loads on gastric emptying [ Time Frame: 240min. ]
    measured by C13 breath test



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy normal weight subjects with a body-mass index of 19.0-24.5 or healthy obese subjects with a body-mass index of > 30
  • Normal eating habits
  • Age 18-40 years
  • Stable body weight for at least three months

Exclusion Criteria:

  • Smoking
  • Substance abuse
  • Regular intake of medications (except for oral contraceptives)
  • Medical or psychiatric illness
  • Any abnormality detected during the screening procedure
  • history of gastrointestinal disorders
  • food allergies

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01875575


Locations
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Switzerland
University Hospital Basel
Basel, Switzerland, CH-4031
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Investigators
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Principal Investigator: Christoph Beglinger, Prof University Hospital, Basel, Switzerland

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier: NCT01875575     History of Changes
Other Study ID Numbers: EKBB 08/11
First Posted: June 12, 2013    Key Record Dates
Last Update Posted: June 12, 2013
Last Verified: June 2013

Keywords provided by University Hospital, Basel, Switzerland:
glucagon-like peptide-1
peptide tyrosine tyrosine
ghrelin
stomach
small intestine
gastric emptying

Additional relevant MeSH terms:
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Endocrine System Diseases