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Functional Magnetic Resonance Imaging Study of Jaw-tapping Movement on Memory Function

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2013 by Seung-Yeon Cho, Kyunghee University Medical Center.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01873664
First Posted: June 10, 2013
Last Update Posted: June 10, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Kyung Hee University Hospital at Gangdong
Information provided by (Responsible Party):
Seung-Yeon Cho, Kyunghee University Medical Center
  Purpose
The purpose of this study is to examine the possibility of using jaw-tapping training as a self-exercise for developing memory and preventing dementia in elderly subjects with memory disturbances using functional magnetic resonance imaging (fMRI).

Condition Intervention
Memory Disturbances Behavioral: Jaw-tapping

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Brain Activity During Jaw Tapping Movement in Healthy Subjects and Mild Cognitive Impairment Patients Using Functional Magnetic Resonance Imaging

Resource links provided by NLM:


Further study details as provided by Seung-Yeon Cho, Kyunghee University Medical Center:

Primary Outcome Measures:
  • Brain activity of n-back task [ Time Frame: up to 4 weeks ]

    All subjects perform the jaw-tapping and the n-back memory tasks during blood oxygen level dependent (BOLD) fMRI, before and after practicing the jaw-tapping exercise for 4 weeks at home.

    Pre- and post-test fMRI data during the n-back task are analyzed using statistical parametric maps of brain activation.



Secondary Outcome Measures:
  • Brain activity of jaw-tapping task [ Time Frame: baseline and 4 weeks ]

    All subjects perform the jaw-tapping and the n-back memory tasks during blood oxygen level dependent (BOLD) fMRI, before and after practicing the jaw-tapping exercise for 4 weeks at home.

    Pre- and post-test fMRI data during the jaw-tapping task are analyzed using statistical parametric maps of brain activation.



Other Outcome Measures:
  • Performance scores of the n-back task [ Time Frame: baseline and 4 weeks ]
    One-back task performance of each subject is assessed by analyzing responses obtained during scanning.


Estimated Enrollment: 30
Study Start Date: May 2009
Estimated Study Completion Date: July 2013
Estimated Primary Completion Date: July 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Jaw tapping
All subjects performed the jaw-tapping for 4 weeks at home.
Behavioral: Jaw-tapping
to tap their jaws vertically at 1.6 Hz at home twice a day for 30 seconds every day during four weeks.

Detailed Description:

Right-handed female volunteers over the age of 50 years with subjective memory complaints are included in the study. Volunteers with dentures, psychoactive medication, history of stroke, or other neurologic disorders are excluded.

The protocol was approved by the Institutional Review Board of university-based hospital.

After administering the Seoul Neuropsychological Screening Battery (SNSB), Mini-Mental State Examination (MMSE) scores above 24 and Clinical Dementia Rating Scale (CDR) scores of 0 are considered subjective memory complaints (SMC), and MMSE scores above 23 and CDR scores of 0.5 are considered MCI.

All subjects undergo two MRI scans. After the first MRI, the subjects are trained to tap their jaws vertically at 1.6 Hz at home twice a day for 30 seconds every day during four weeks.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Right-handed female volunteers over the age of 50 years with subjective memory complaints

Exclusion Criteria:

  • Volunteers with dentures, psychoactive medication, history of stroke, or other neurologic disorders
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01873664


Contacts
Contact: Seung-Yeon Cho, Ph.D +82 2 440 6209 sycho83@gmail.com

Locations
Korea, Republic of
Kyung Hee University Hospital at Gangdong Recruiting
Seoul, Korea, Republic of, 134-727
Contact: Seung-Yeon Cho, Ph.D       sycho83@gmail.com   
Sponsors and Collaborators
Kyunghee University Medical Center
Kyung Hee University Hospital at Gangdong
Investigators
Principal Investigator: Jung-Mi Park, Ph.D Professor, Kyung Hee University
  More Information

Responsible Party: Seung-Yeon Cho, fellow, Kyung Hee University Hospital at Gangdong, Kyunghee University Medical Center
ClinicalTrials.gov Identifier: NCT01873664     History of Changes
Other Study ID Numbers: NRF-2010-0017278
First Submitted: June 3, 2013
First Posted: June 10, 2013
Last Update Posted: June 10, 2013
Last Verified: June 2013

Keywords provided by Seung-Yeon Cho, Kyunghee University Medical Center:
fMRI
Jaw tapping
Memory disorder
Mild cognitive impairment
MCI
Working memory

Additional relevant MeSH terms:
Cognitive Dysfunction
Cognition Disorders
Neurocognitive Disorders
Mental Disorders