Functional Magnetic Resonance Imaging Study of Jaw-tapping Movement on Memory Function
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ClinicalTrials.gov Identifier: NCT01873664 |
Recruitment Status
: Unknown
Verified June 2013 by Seung-Yeon Cho, Kyunghee University Medical Center.
Recruitment status was: Recruiting
First Posted
: June 10, 2013
Last Update Posted
: June 10, 2013
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Memory Disturbances | Behavioral: Jaw-tapping | Not Applicable |
Right-handed female volunteers over the age of 50 years with subjective memory complaints are included in the study. Volunteers with dentures, psychoactive medication, history of stroke, or other neurologic disorders are excluded.
The protocol was approved by the Institutional Review Board of university-based hospital.
After administering the Seoul Neuropsychological Screening Battery (SNSB), Mini-Mental State Examination (MMSE) scores above 24 and Clinical Dementia Rating Scale (CDR) scores of 0 are considered subjective memory complaints (SMC), and MMSE scores above 23 and CDR scores of 0.5 are considered MCI.
All subjects undergo two MRI scans. After the first MRI, the subjects are trained to tap their jaws vertically at 1.6 Hz at home twice a day for 30 seconds every day during four weeks.
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 30 participants |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Prevention |
Official Title: | Brain Activity During Jaw Tapping Movement in Healthy Subjects and Mild Cognitive Impairment Patients Using Functional Magnetic Resonance Imaging |
Study Start Date : | May 2009 |
Estimated Primary Completion Date : | July 2013 |
Estimated Study Completion Date : | July 2013 |
Arm | Intervention/treatment |
---|---|
Experimental: Jaw tapping
All subjects performed the jaw-tapping for 4 weeks at home.
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Behavioral: Jaw-tapping
to tap their jaws vertically at 1.6 Hz at home twice a day for 30 seconds every day during four weeks.
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- Brain activity of n-back task [ Time Frame: up to 4 weeks ]
All subjects perform the jaw-tapping and the n-back memory tasks during blood oxygen level dependent (BOLD) fMRI, before and after practicing the jaw-tapping exercise for 4 weeks at home.
Pre- and post-test fMRI data during the n-back task are analyzed using statistical parametric maps of brain activation.
- Brain activity of jaw-tapping task [ Time Frame: baseline and 4 weeks ]
All subjects perform the jaw-tapping and the n-back memory tasks during blood oxygen level dependent (BOLD) fMRI, before and after practicing the jaw-tapping exercise for 4 weeks at home.
Pre- and post-test fMRI data during the jaw-tapping task are analyzed using statistical parametric maps of brain activation.
- Performance scores of the n-back task [ Time Frame: baseline and 4 weeks ]One-back task performance of each subject is assessed by analyzing responses obtained during scanning.

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Ages Eligible for Study: | 50 Years and older (Adult, Senior) |
Sexes Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Right-handed female volunteers over the age of 50 years with subjective memory complaints
Exclusion Criteria:
- Volunteers with dentures, psychoactive medication, history of stroke, or other neurologic disorders

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01873664
Contact: Seung-Yeon Cho, Ph.D | +82 2 440 6209 | sycho83@gmail.com |
Korea, Republic of | |
Kyung Hee University Hospital at Gangdong | Recruiting |
Seoul, Korea, Republic of, 134-727 | |
Contact: Seung-Yeon Cho, Ph.D sycho83@gmail.com |
Principal Investigator: | Jung-Mi Park, Ph.D | Professor, Kyung Hee University |
Responsible Party: | Seung-Yeon Cho, fellow, Kyung Hee University Hospital at Gangdong, Kyunghee University Medical Center |
ClinicalTrials.gov Identifier: | NCT01873664 History of Changes |
Other Study ID Numbers: |
NRF-2010-0017278 |
First Posted: | June 10, 2013 Key Record Dates |
Last Update Posted: | June 10, 2013 |
Last Verified: | June 2013 |
Keywords provided by Seung-Yeon Cho, Kyunghee University Medical Center:
fMRI Jaw tapping Memory disorder |
Mild cognitive impairment MCI Working memory |
Additional relevant MeSH terms:
Cognitive Dysfunction Cognition Disorders Neurocognitive Disorders Mental Disorders |