Functional Magnetic Resonance Imaging Study of Jaw-tapping Movement on Memory Function

Study Description

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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Brief Summary:

The purpose of this study is to examine the possibility of using jaw-tapping training as a self-exercise for developing memory and preventing dementia in elderly subjects with memory disturbances using functional magnetic resonance imaging (fMRI).

Condition or disease	Intervention/treatment	Phase
Memory Disturbances	Behavioral: Jaw-tapping	Not Applicable

Detailed Description:

Right-handed female volunteers over the age of 50 years with subjective memory complaints are included in the study. Volunteers with dentures, psychoactive medication, history of stroke, or other neurologic disorders are excluded.

The protocol was approved by the Institutional Review Board of university-based hospital.

After administering the Seoul Neuropsychological Screening Battery (SNSB), Mini-Mental State Examination (MMSE) scores above 24 and Clinical Dementia Rating Scale (CDR) scores of 0 are considered subjective memory complaints (SMC), and MMSE scores above 23 and CDR scores of 0.5 are considered MCI.

All subjects undergo two MRI scans. After the first MRI, the subjects are trained to tap their jaws vertically at 1.6 Hz at home twice a day for 30 seconds every day during four weeks.

Study Design

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Study Type :	Interventional (Clinical Trial)
Estimated Enrollment :	30 participants
Intervention Model:	Single Group Assignment
Masking:	None (Open Label)
Primary Purpose:	Prevention
Official Title:	Brain Activity During Jaw Tapping Movement in Healthy Subjects and Mild Cognitive Impairment Patients Using Functional Magnetic Resonance Imaging
Study Start Date :	May 2009
Estimated Primary Completion Date :	July 2013
Estimated Study Completion Date :	July 2013

Arms and Interventions

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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Arm	Intervention/treatment
Experimental: Jaw tapping; All subjects performed the jaw-tapping for 4 weeks at home.	Behavioral: Jaw-tapping; to tap their jaws vertically at 1.6 Hz at home twice a day for 30 seconds every day during four weeks.

Outcome Measures

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Primary Outcome Measures :

1. Brain activity of n-back task [ Time Frame: up to 4 weeks ]

   All subjects perform the jaw-tapping and the n-back memory tasks during blood oxygen level dependent (BOLD) fMRI, before and after practicing the jaw-tapping exercise for 4 weeks at home.

   Pre- and post-test fMRI data during the n-back task are analyzed using statistical parametric maps of brain activation.

Secondary Outcome Measures :

1. Brain activity of jaw-tapping task [ Time Frame: baseline and 4 weeks ]

   All subjects perform the jaw-tapping and the n-back memory tasks during blood oxygen level dependent (BOLD) fMRI, before and after practicing the jaw-tapping exercise for 4 weeks at home.

   Pre- and post-test fMRI data during the jaw-tapping task are analyzed using statistical parametric maps of brain activation.

Other Outcome Measures:

1. Performance scores of the n-back task [ Time Frame: baseline and 4 weeks ]
   One-back task performance of each subject is assessed by analyzing responses obtained during scanning.

Eligibility Criteria

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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Ages Eligible for Study:	50 Years and older (Adult, Senior)
Sexes Eligible for Study:	Female
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

• Right-handed female volunteers over the age of 50 years with subjective memory complaints

Exclusion Criteria:

• Volunteers with dentures, psychoactive medication, history of stroke, or other neurologic disorders

Contacts and Locations

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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Contacts

Contact: Seung-Yeon Cho, Ph.D	+82 2 440 6209	sycho83@gmail.com

Locations

Korea, Republic of
Kyung Hee University Hospital at Gangdong	Recruiting
Seoul, Korea, Republic of, 134-727
Contact: Seung-Yeon Cho, Ph.D sycho83@gmail.com

Sponsors and Collaborators

Kyunghee University Medical Center

Kyung Hee University Hospital at Gangdong

Investigators

Principal Investigator:	Jung-Mi Park, Ph.D	Professor, Kyung Hee University

More Information

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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Responsible Party:	Seung-Yeon Cho, fellow, Kyung Hee University Hospital at Gangdong, Kyunghee University Medical Center
ClinicalTrials.gov Identifier:	NCT01873664 History of Changes
Other Study ID Numbers:	NRF-2010-0017278
First Posted:	June 10, 2013
Last Update Posted:	June 10, 2013
Last Verified:	June 2013

Keywords provided by Seung-Yeon Cho, Kyunghee University Medical Center:

fMRI; Jaw tapping; Memory disorder	Mild cognitive impairment; MCI; Working memory

Additional relevant MeSH terms:

Cognitive Dysfunction; Cognition Disorders; Neurocognitive Disorders; Mental Disorders