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Postpartum Screening of Type 2 Diabetes (Tot ou tard)

This study is ongoing, but not recruiting participants.
The Lawson Foundation
Information provided by (Responsible Party):
Jean-Luc Ardilouze, Université de Sherbrooke Identifier:
First received: May 15, 2013
Last updated: December 22, 2016
Last verified: December 2016

Gestational diabetes mellitus (GDM) complicates 5 to 30 % of pregnancies. GDM is defined as hyperglycemia with onset or first recognition during pregnancy. Because it is a forerunner of type 2 diabetes mellitus (T2DM), professional associations recommend T2DM postpartum screening (T2DM-pPS) at 6 weeks/6 months post delivery, using a 75g oral glucose tolerance test (OGTT).

However, less than a quarter of these women are screened. This recommendation has failed for multiple reasons; the most important being that busy new mothers must deal with the major inconveniences of returning to a sampling center for a 2h testing session, bringing baby along or paying for a sitter, transportation, parking… A mother-friendly solution is direly needed.

The investigators hypothesize that, in these women, results of an OGTT performed after delivery on the last day of their hospital stay (OGTT-1) will predict results of the recommended OGTT (OGTT-2) at 6 weeks/6 months postpartum.

The main aim of our project is to determine the optimal cut-off value for the 2h glucose result during OGTT-1 in order to predict abnormal glucose tolerance status at OGTT-2 (the gold standard), in the same woman.

Condition Intervention
Type 2 Diabetes Procedure: oral glucose tolerance test 2 days post-partum

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Can we Screen Type 2 Diabetes on the 2nd Day After Delivery in Women Who Had Gestational Diabetes Mellitus?

Resource links provided by NLM:

Further study details as provided by Jean-Luc Ardilouze, Université de Sherbrooke:

Primary Outcome Measures:
  • Diagnosis of abnormal glucose tolerance [ Time Frame: 12 weeks postpartum ]
    Oral glucose tolerance test

Secondary Outcome Measures:
  • Patient's satisfaction [ Time Frame: 12 weeks post-partum ]
    Satisfaction questionnaire

Estimated Enrollment: 145
Study Start Date: April 2014
Estimated Study Completion Date: December 2017
Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: postpartum screening
Oral glucose tolerance test 2 days post-partum
Procedure: oral glucose tolerance test 2 days post-partum
Screening for type 2 diabetes after gestational diabetes mellitus.


Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Women aged between 18 and 45 years;
  • Having a positive diagnosis of gestational diabetes mellitus (IADPSG criteria);
  • Treated with diet or insulin;
  • Have given birth to a child at term; gestational age > 37 weeks;
  • Have been followed during her pregnancy by a physician who delivers in CHUS;
  • Have signed the consent form.

Exclusion Criteria:

  • History of glucose intolerance or diabetes before the pregnancy;
  • Have presented another obstetrical pathology during the pregnancy;

    • Severe gestational high blood pressure with proteinuria;
    • Delayed intrauterine development syndrome;
    • Pregnancy with more than a foetus;
    • Drug addiction;
    • Had complications during the delivery such as:
  • Moderate to severe postpartum bleeding;
  • Surgery in postpartum (curettage, hysterectomy, etc.).
  Contacts and Locations
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Please refer to this study by its identifier: NCT01869608

Canada, Quebec
Clinical Research Center Étienne-Le Bel of the Sherbrooke University Hospital
Sherbrooke, Quebec, Canada, J1H 5N4
Sponsors and Collaborators
Université de Sherbrooke
The Lawson Foundation
Principal Investigator: Jean-Luc Ardilouze, MD, PhD Clinical Research Center Étienne-Le Bel of the Sherbrooke University Hospital
  More Information

Responsible Party: Jean-Luc Ardilouze, Full professor, endocrinologist, researcher, Université de Sherbrooke Identifier: NCT01869608     History of Changes
Other Study ID Numbers: 13-005
Study First Received: May 15, 2013
Last Updated: December 22, 2016

Keywords provided by Jean-Luc Ardilouze, Université de Sherbrooke:
postpartum screening
type 2 diabetes

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases processed this record on September 19, 2017