DTI of the Brain and Cervical Spine: Evaluation in Normal Subjects and Patients With Cervical Spondylotic Myelopathy
More than half of the middle-aged population has radiologic evidence of cervical spondylosis (Irvine 1965) and a subset of this population develops cervical spondylotic myelopathy (CSM), a condition in which the spinal cord is impaired, either by direct mechanical compression or indirectly by arterial deprivation and/or venous stasis. In this study we aim to test the hypothesis that diffusion tensor imaging can provide prognostic information on the integrity of the spine in these patients which is unavailable from conventional MRI images
Cervical Spondylosis With Myelopathy
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Diffusion Tensor Imaging of the Brain and Cervical Spine: Evaluation of Reproducibility in Normal Subjects and Diagnostic Utility in Patients With Cervical Spondylotic Myelopathy|
- Diffusion properties of the spinal cord [ Time Frame: The diffusion properties are measured in a single imaging session lasting approximately 50 minutes. ] [ Designated as safety issue: No ]
Two parameters characterizing the diffusion of water in the spinal cord will be studied.
- The fractional anisotropy reflects the orientational motion of water and the average value will be assessed over the length of the cervical spine for both the control and patient groups. This quantity has no units.
- The trace of the diffusion tensor. This measures the mean diffusivity of the water in the spinal cord and is measured in m^2/sec.
|Study Start Date:||January 2013|
|Estimated Study Completion Date:||December 2015|
|Estimated Primary Completion Date:||June 2015 (Final data collection date for primary outcome measure)|
Subjects with clinical indications of cervical spondylotic myelopathy (CSM).
Aged matched to the CSM group but with no signs of CSM
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01868958
|Contact: Angie Williams, BScfirstname.lastname@example.org|
|Contact: Kyle Webb, MScemail@example.com|
|United States, Georgia|
|Center for Systems Imaging (CSI), Emory University||Recruiting|
|Atlanta, Georgia, United States, 30329|
|Principal Investigator:||Richard A Jones, PhD||Department of Radiology, Emory University|