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DTI of the Brain and Cervical Spine: Evaluation in Normal Subjects and Patients With Cervical Spondylotic Myelopathy

This study has been completed.
Siemens Medical Solutions
Information provided by (Responsible Party):
Richard Jones, Emory University Identifier:
First received: May 13, 2013
Last updated: July 14, 2015
Last verified: July 2015
More than half of the middle-aged population has radiologic evidence of cervical spondylosis (Irvine 1965) and a subset of this population develops cervical spondylotic myelopathy (CSM), a condition in which the spinal cord is impaired, either by direct mechanical compression or indirectly by arterial deprivation and/or venous stasis. In this study we aim to test the hypothesis that diffusion tensor imaging can provide prognostic information on the integrity of the spine in these patients which is unavailable from conventional MRI images

Cervical Spondylosis With Myelopathy

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Diffusion Tensor Imaging of the Brain and Cervical Spine: Evaluation of Reproducibility in Normal Subjects and Diagnostic Utility in Patients With Cervical Spondylotic Myelopathy

Resource links provided by NLM:

Further study details as provided by Emory University:

Primary Outcome Measures:
  • Diffusion properties of the spinal cord [ Time Frame: The diffusion properties are measured in a single imaging session lasting approximately 50 minutes. ]

    Two parameters characterizing the diffusion of water in the spinal cord will be studied.

    1. The fractional anisotropy reflects the orientational motion of water and the average value will be assessed over the length of the cervical spine for both the control and patient groups. This quantity has no units.
    2. The trace of the diffusion tensor. This measures the mean diffusivity of the water in the spinal cord and is measured in m^2/sec.

Enrollment: 26
Study Start Date: January 2013
Study Completion Date: June 2015
Primary Completion Date: June 2015 (Final data collection date for primary outcome measure)
CSM subjects
Subjects with clinical indications of cervical spondylotic myelopathy (CSM).
Control group
Aged matched to the CSM group but with no signs of CSM

  Show Detailed Description


Ages Eligible for Study:   30 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients at the Emory Orthopaedics & Spine Center suffering signs and symptoms of cervical myelopathy and with evidence of radiographic cervical cord compression with or without abnormal spinal cord signal intensity secondary to spondylosis.

Inclusion Criteria:

  • 20 patients will be selected by an experienced team of orthopedic specialist from the Emory Orthopaedics & Spine Center and will include patients suffering signs and symptoms of cervical myelopathy and with evidence of radiographic cervical cord compression with or without abnormal spinal cord signal intensity secondary to spondylosis.
  • 20 controls : Aged matched to the patient group. No history of CSM.

Exclusion Criteria:

  • Any history of significant trauma implicating the brain or cervical spine, including prior motor vehicle collision and history of prior brain, neck or cervical spine surgery.
  • Any history of neurological disease
  • Dental braces or similar orthodontic devices.
  • Claustrophobia
  Contacts and Locations
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Please refer to this study by its identifier: NCT01868958

United States, Georgia
Center for Systems Imaging (CSI), Emory University
Atlanta, Georgia, United States, 30329
Sponsors and Collaborators
Emory University
Siemens Medical Solutions
Principal Investigator: Richard A Jones, PhD Department of Radiology, Emory University
  More Information

Responsible Party: Richard Jones, Assistant professor of Radiology, Emory University Identifier: NCT01868958     History of Changes
Other Study ID Numbers: IRB00058267
Study First Received: May 13, 2013
Last Updated: July 14, 2015

Keywords provided by Emory University:
Magnetic resonance imaging (MRI)
Diffusion tensor imaging

Additional relevant MeSH terms:
Spinal Cord Diseases
Bone Marrow Diseases
Spinal Osteophytosis
Spinal Diseases
Bone Diseases
Musculoskeletal Diseases
Central Nervous System Diseases
Nervous System Diseases
Hematologic Diseases processed this record on April 25, 2017