Relationship Analysis Between Periodontal Disease and Atherosclerosis in Japanese Medical Cooperation Services (RAPA-JMCS)
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|ClinicalTrials.gov Identifier: NCT01866761|
Recruitment Status : Completed
First Posted : May 31, 2013
Last Update Posted : May 31, 2013
Objective: We aimed at analyzing the relationship between periodontal disease and atherosclerosis in medical treatment and periodontal treatment under medical and dental care across borders in a local cooperation system of Japanese medical services.
Materials and methods:
- A prospective multi-center case cohort study was conducted on 37 ambulatory medical patients (with lifestyle-related diseases under consultation in either of the medical clinics registered as collaborative investigation facilities) and 79 periodontal patients (who were seen by the dental clinics registered as collaborative investigation facilities).
- Medical treatment and clinical periodontal treatment were provided on the subjects under medical and dental care across borders by each internal medicine and dental clinics.
- Systemic examination of lifestyle-related disease and periodontal examination were performed before and after periodontal treatment, and the relationships between periodontal and atherosclerosis-related clinical markers were analyzed before and after periodontal treatment.
|Condition or disease||Intervention/treatment|
|Periodontal Disease Atherosclerosis||Procedure: Periodontal treatment|
|Study Type :||Observational [Patient Registry]|
|Actual Enrollment :||116 participants|
|Target Follow-Up Duration:||2 Years|
|Official Title:||Analysis of the Relationship Between Periodontal Disease and Atherosclerosis Within a Local Cooperation System of Japanese Medical Services|
|Study Start Date :||November 2008|
|Actual Primary Completion Date :||January 2012|
|Periodontitis, Lifestyle-related disease||
Procedure: Periodontal treatment
- Relation between probing pocket depth and anti-periodontopathic bacteria IgG antibody titer for periodontitis and the MAX intima-media thickness, urea sugar, urea protein, urea occult blood, creatinine, and eGFR for atherosclerosis [ Time Frame: an expected average of 1.5 year ]At following 3-time points; Baseline, After initial preparation of periodontal treatment, Starting point of supportive periodontal therapy
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01866761
|Okayama University of Graduate School of Medicine, Dentistry and Pharmaceutical Sciences|
|Okayama, Japan, 700-8525|