Natural Cycle In Vitro Fertilization
|ClinicalTrials.gov Identifier: NCT01866618|
Recruitment Status : Completed
First Posted : May 31, 2013
Last Update Posted : April 9, 2018
|Condition or disease|
|Natural Cycle in Vitro Fertilization (IVF)|
|Study Type :||Observational|
|Actual Enrollment :||524 participants|
|Official Title:||Natural Cycle In Vitro Fertilization|
|Study Start Date :||April 2013|
|Actual Primary Completion Date :||August 2016|
|Actual Study Completion Date :||December 2016|
Natural IVF Cycle
All patients will undergo a natural IVF cycle using trigger shots of Leuprolide Acetate(Lupron) and human chorionic gonadotropin (hCG) to ensure the patient surges.
- Endometrial Changes [ Time Frame: 1 Year ]To examine the endometrium within the natural cycle in order to accurately characterize the differences in multiple aspects of endocrine and paracrine hormonal activity, the transcriptome of cells influencing oocyte maturation and changes in the endometrium.
- Aneuploidy Rates [ Time Frame: 1 Year ]To examine aneuploidy rates in embryos from natural IVF cycles.
- Temporal Embryonic Development [ Time Frame: 1 Year ]To examine the parameters of temporal embryonic development and the transcriptome of granulosa cells and follicular fluid. The embryos will be graded at standard time points to determine whether there are differences in in vitro development. Granulosa cells and follicular fluid will undergo gene expression analysis and compared to the gene expression profiles found in those specimens in stimulated cycles.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01866618
|United States, New Jersey|
|Reproductive Medicine Associates of New Jersey|
|Basking Ridge, New Jersey, United States, 07920|
|Principal Investigator:||Richard T Scott, M.D., HCLD||Reproductive Medicine Associates of New Jersey|