Proton Pump Inhibitor (PPI) Responsive Eosinophilic Esophagitis EoE: Gastroesophageal Reflux Disease (GERD) or Eosinophilic Esophagitis (EoE)?
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|ClinicalTrials.gov Identifier: NCT01865825|
Recruitment Status : Completed
First Posted : May 31, 2013
Last Update Posted : March 22, 2017
The investigators would like to determine if there are patients with PPI responsive Eosinophilic Esophagitis Infiltration that have significant loss of esophageal distensibility suggestive of esophageal fibrosis typical of classic Eosniophilic Esophagitis.
If this group of patients exists, the investigators would like to determine if they have the typical endoscopic features of EoE rather than those of GERD.
|Condition or disease||Intervention/treatment|
|Erosive Esophagitis||Radiation: Esophageal Barium Xray|
|Study Type :||Observational|
|Actual Enrollment :||20 participants|
|Official Title:||PPI Responsive Esophageal Eosinophilia: GERD or Eosinophilic Esophagitis?|
|Actual Study Start Date :||March 2013|
|Actual Primary Completion Date :||December 2016|
|Actual Study Completion Date :||March 2017|
Esophageal barium xray
We will recruit 20 patients with GERD without dysphagia for an esophageal barium xray for esophageal diameter measurements.
The 20 Gastroesophageal Reflux Disease (GERD) patients will complete the Mayo Dysphagia Questionnaire 30-day and the Eosinophilic Esophagitis Actitivy Index (EEsAI) questionnaires
Radiation: Esophageal Barium Xray
•Fast for 4 hours prior to the Esophagram (upper GI x-ray). You will drink a liquid that has barium or another contrast agent in it. The radiologist will use the X-ray machine to look at your upper GI tract while you drink the contrast liquid. The x-ray exam should take between 10-15 minutes.
We will have patients complete the Mayo Dysphasia Questionnaire-30 day.
- Abnormal esophageal distensibility in patients with PPI responsive Eosinophilic Infiltrates to patients with Eosionophilic esophagitis and Gastroesophageal Reflux Disease. [ Time Frame: 1 year ]We will evaluate endoscopic features of Gastroesophageal Reflux Disease(GERD) by reviewing endoscopic reports and images. The presence of esophageal narrowing, furrows, rings, fragility, and white spots will be noted form the endoscopic reports prior to the initiation of the Provation report system. We will review the endoscopic reports and the endoscopic photographs on those patients evaluated after the Provation report system was initiated. All images will be reviewed by one investigator unaware of the subjects clinical data and name
- The relationship of abnormal esophageal distensibility to other endoscopic findings of EoE (furrows, rings, fragility, stricture) [ Time Frame: 1 year ]After reviewing endoscopic features of GERD by reviewing endoscopic reports and images. The presence of esophageal narrowing, furrows, rings, fragility, and white spots will be noted form the endoscopic reports prior to the initiation of the Provation report system. We will determine the relationship of abnormal esophagus distensibility to the endoscopic findings
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01865825
|United States, Minnesota|
|Rochester, Minnesota, United States, 55905|
|Principal Investigator:||Jeffrey Alexander, MD||Mayo Clinic|