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Impact of tDCS on Cerebral Autoregulation

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ClinicalTrials.gov Identifier: NCT01865604
Recruitment Status : Completed
First Posted : May 31, 2013
Last Update Posted : March 16, 2016
Information provided by (Responsible Party):
Agnes Flöel, Charite University, Berlin, Germany

Brief Summary:
The aim of the study is to investigate whether there is a polarity-specific influence of tDCS on cerebral vasomotor reactivity monitored by transcranial doppler sonography.

Condition or disease Intervention/treatment
Cerebral Microangiopathy CADASIL Migraine With Aura ICA Stenosis Device: Anodal tDCS Device: Cathodal tDCS Device: sham tDCS

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
Study Start Date : April 2012
Primary Completion Date : March 2014
Study Completion Date : March 2014

Arm Intervention/treatment
Experimental: Anodal tDCS
anaodal transcranial direct current stimulation
Device: Anodal tDCS
Active Comparator: Cathodal tDCS
cathodal transcranial direct current stimulation
Device: Cathodal tDCS
Sham Comparator: Sham tDCS
no stimulation
Device: sham tDCS

Primary Outcome Measures :
  1. Cerebral vasomotor reactivity assessed by transcranial Dopplersonography [ Time Frame: on 3 days within 12 weeks ]
    comparing cerebral vasomotor reactivity at baseline and after anodal/cathodal/sham stimulation

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  1. severe cerebral Microangiopathy
  2. NOTCH3 carrier
  3. Migraine with aura (IHS Classification ICHD-II)
  4. Stenosis >80%, ECST-Criteria

Exclusion Criteria:

  • seizure disorder
  • history of severe alcohol or drug abuse, psychiatric illness like severe depression, poor motivational capacity
  • dementia

(1+2) history of stroke in past 3 months (3) migraine prophylaxis (4) contralateral stenosis >50%,

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01865604

Department of Neurology, Charité Universitätsmedizin Berlin
Berlin, Germany, 10117
Sponsors and Collaborators
Charite University, Berlin, Germany
Principal Investigator: Agnes Flöel, Prof. MD Charite University, Berlin, Germany

Responsible Party: Agnes Flöel, Prof. Dr. med. Agnes Floeel, Charite University, Berlin, Germany
ClinicalTrials.gov Identifier: NCT01865604     History of Changes
Other Study ID Numbers: tDCS_cVMR
First Posted: May 31, 2013    Key Record Dates
Last Update Posted: March 16, 2016
Last Verified: March 2016

Additional relevant MeSH terms:
Migraine with Aura
Cerebral Small Vessel Diseases
Migraine Disorders
Headache Disorders, Primary
Headache Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Cerebrovascular Disorders
Dementia, Vascular
Cerebral Arterial Diseases
Intracranial Arterial Diseases
Vascular Diseases
Cardiovascular Diseases
Genetic Diseases, Inborn