Effects of Octanoic Acid for Treatment of Essential Voice Tremor
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|ClinicalTrials.gov Identifier: NCT01864525|
Recruitment Status : Completed
First Posted : May 29, 2013
Last Update Posted : April 27, 2017
|Condition or disease||Intervention/treatment||Phase|
|Essential Voice Tremor Vocal Tremor Voice Tremor Essential Tremor of Voice||Drug: Octanoic acid Drug: Placebo pill||Phase 1 Phase 2|
- Essential tremor of the voice produces regular shaking and hoarseness in the voice, making it difficult speech difficult to understand
- Several previous studies have found that octanoic acid and octanol, which are related to alcohol, can improve tremor in some people without producing many side effects and without producing intoxication
- Researchers are interested in determining whether octanoic acid can improve tremor that affects the voice
- To determine the effects of octanoic voice using voice recordings and listener ratings of voice
- To determine the effects of octanoic acid on level of voice disability experienced by people with essential voice tremor
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||17 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||Effects of Octanoic Acid for Treatment of Essential Voice Tremor|
|Study Start Date :||July 2013|
|Actual Primary Completion Date :||March 31, 2017|
|Actual Study Completion Date :||March 31, 2017|
Placebo Comparator: Inactive pill
Participants will receive a pill/capsule with an inactive ingredient during the placebo arm of this study.
Drug: Placebo pill
Experimental: Octanoic acid
Participants will receive a pill/capsule with octanoic acid (amount determined by the participant's weight) during the experimental arm of this study.
Drug: Octanoic acid
Other Name: Caprylic acid
- Pre- to post-treatment change in the acoustic characteristics of voice tremor [ Time Frame: Up to 1 year ]Voice recordings will be used to measure the degree of tremor in the voice. Degree of change from pre- to post-treatment will be compared for the octanoic acid and placebo conditions.
- Pre- to post-treatment change in the auditory-perceptual characteristics of voice tremor [ Time Frame: Up to 3 years ]Listeners will rate the voice from comparisons of recordings before and after each condition. Degree of change from pre- to post-treatment will be compared for the octanoic acid and placebo conditions.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01864525
|United States, New York|
|Syracuse University & Upstate Medical University|
|Syracuse, New York, United States, 13210|
|Principal Investigator:||Soren Y Lowell, PhD||Syracuse University|