Comparison of Optic Nerve Sheath Diameter on Retrobulbar Ultrasound Before and After Drainage of Cerebrospinal Fluid in Patient With Hydrocephalus

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2013 by Yonsei University
Information provided by (Responsible Party):
Yonsei University Identifier:
First received: May 22, 2013
Last updated: May 24, 2013
Last verified: May 2013

Studies in patients with intracranial hypertension have shown a good relationship between optic nerve sheath diameter measured by retrobulbar ultrasound and invasively measured intracranial pressure. The aim of this study was to evaluate changes in optic nerve sheath diameter before and after drainage of cerebrospinal fluid in patients with hydrocephalus.

Condition Intervention
Procedure: retrobulbar ultrasound

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Yonsei University:

Primary Outcome Measures:
  • both optic nerve sheath diameter (the posterior 3mm of the papilla) [ Time Frame: from induction of general anesthesia to average 15 min after recovery of general anesthesia ] [ Designated as safety issue: No ]

Estimated Enrollment: 38
Study Start Date: March 2013
Estimated Study Completion Date: March 2014
Estimated Primary Completion Date: March 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
both optic nerve sheath diameter
both optic nerve sheath diameter (the posterior 3mm of the papilla), 5 individual measurement
Procedure: retrobulbar ultrasound
both optic nerve sheath diameter (the posterior 3mm of the papilla), 5 individual measurement


Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

patient with hydrocephalus


Inclusion Criteria:

  1. ASA Ⅰ-Ⅱ
  2. aged between 20 and 70 year
  3. hydrocephalus
  4. general anesthesia for undergoing drainage of cerebrospinal fluid

Exclusion Criteria:

1. an anatomical or functional abnormality in optic nerve

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01863329

Contact: Hyunzu Kim, MD 82-2-2228-2422,

Korea, Republic of
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine Recruiting
Seoul, Korea, Republic of, 120-752
Contact: Hyunzu Kim, MD    82-2-2228-2422   
Sponsors and Collaborators
Yonsei University
  More Information

No publications provided

Responsible Party: Yonsei University Identifier: NCT01863329     History of Changes
Other Study ID Numbers: 4-2013-0006
Study First Received: May 22, 2013
Last Updated: May 24, 2013
Health Authority: Korea: Institutional Review Board

Keywords provided by Yonsei University:
Optic nerve sheath diameter
Intracranial hypertension

Additional relevant MeSH terms:
Brain Diseases
Central Nervous System Diseases
Intracranial Hypertension
Nervous System Diseases processed this record on March 26, 2015