Pilot Study of Strength Testing in Overweight Women With or Without Insulin Resistance
- Some people who are obese may have decreased muscle strength. They may have greater muscle mass shown in scans, but they show poor results in exercise tests. Poor muscle strength might cause some of the difficulty with exercise performance. Researchers want to test muscle strength in the arms and legs of overweight women. They will also see how insulin resistance affects muscle strength in these women.
- To test muscle strength in overweight women.
- To see if insulin resistance affects muscle strength.
- Women at least 18 years of age who are overweight (body mass index greater than 25 kg/m2).
- Participants will be asked to fast before having an initial blood test to measure glucose and insulin levels.
- On a different day, they will have the strength testing. The first test will measure leg muscle strength by testing the quadriceps and the hamstrings. The second test will measure arm muscle strength by testing the biceps and triceps. The final test will measure hand muscle (grip) strength.
- All the tests should take about an hour.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Pilot Study of Strength Testing in Overweight Women With or Without Insulin Resistance|
- To determine whether increased extremity muscle mass associated with obesity, diminished insulin sensitivity and high insulin levels is associated with diminished strength. [ Time Frame: ongoing ] [ Designated as safety issue: No ]
|Study Start Date:||May 2013|
|Study Completion Date:||March 2015|
|Primary Completion Date:||June 2013 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01862757
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|
|Principal Investigator:||Richard O Cannon, M.D.||National Heart, Lung, and Blood Institute (NHLBI)|