Detection of Celiac Disease in Patients With Hypothyroidism
The study evaluates whether hypothyroid patients requiring elevated doses of levothyroxine to maintain a euthyroid state are at increased risk of having celiac disease. It also attempts to determine if there is a threshold level of levothyroxine needed to maintain a euthyroid state in patients with hypothyroidism that should prompt serologic testing for celiac disease.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Detection of Celiac Disease in Patients With Hypothyroidism|
- presence of celiac disease [ Time Frame: 1 month ] [ Designated as safety issue: No ]
- Symptoms associated with celiac disease [ Time Frame: 6 months ] [ Designated as safety issue: No ]a short questionnaire will be filled out at the time of serologic testing. If a patient hads celiac disease the form will be filled out again at 6 months after diagnosis.
- medication adjustment [ Time Frame: 6 months ] [ Designated as safety issue: No ]Patients diagnosed with celiac disease who initiate a gluten free diet will be assessed to determine whether adjustment of levothyroxine dosing is necessary
|Study Start Date:||March 2012|
|Study Completion Date:||December 2014|
|Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
This study is looking at whether hypothyroid patients who require above 125 mcg/day (or >1.5mcg/kg/day) of levothyroxine are more likely to have celiac disease than those who require smaller doses. It also looks to see if the prevalence of celiac disease in hypothyroid patients who require elevated doses of levothyroxine is high enough to warrant screening in that population.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01862510
|United States, Vermont|
|Fletcher Allen Health Care|
|Burlington, Vermont, United States, 05405|
|Principal Investigator:||Richard Zubarik, MD||University of Vermont|