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Reducing Mesh Infections in Open Hernia Repairs

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2013 by Ali Cadili, University of Saskatchewan.
Recruitment status was:  Not yet recruiting
Information provided by (Responsible Party):
Ali Cadili, University of Saskatchewan Identifier:
First received: May 18, 2013
Last updated: NA
Last verified: May 2013
History: No changes posted
Soaking meshes in a vancomycin solution just prior to their use in open hernia repairs will decrease rates of mesh infection

Condition Intervention Phase
Patients Undergoing Open Hernia Repair Patients Undergoing Ventral or Inguinal Hernia Repair Procedure: vancomycin-soaked mesh Procedure: plain mesh Phase 2 Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Prevention
Official Title: Does Soaking Synthetic Mesh in Vancomycin Solution Reduce Mesh Infections in Open Hernia Repairs?

Resource links provided by NLM:

Further study details as provided by Ali Cadili, University of Saskatchewan:

Primary Outcome Measures:
  • mesh infections [ Time Frame: 6 months ]

Secondary Outcome Measures:
  • hernia recurrence [ Time Frame: 6 months ]
  • postoperative seroma formation [ Time Frame: 6 months ]

Study Start Date: June 2013
Estimated Primary Completion Date: June 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: plain mesh
standard practice of using plain mesh (non vancomycin-soaked) for open hernia repair
Procedure: plain mesh
Other Name: non vancomycin-soaked mesh
Experimental: vancomycin-soaked mesh
use of vancomycin-soaked mesh for open hernia repair
Procedure: vancomycin-soaked mesh


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • open ventral or inguinal hernia repair

Exclusion Criteria:

  • laparoscopic hernia repair
  • non ventral or inguinal hernia repairs
  Contacts and Locations
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Please refer to this study by its identifier: NCT01860469

Canada, Saskatchewan
Five Hills Health Region Not yet recruiting
Moose Jaw, Saskatchewan, Canada, S6H 1H3
Contact: Ali Cadili, MD, FRCSC    3066940200   
Principal Investigator: Ali Cadili, MD, FRCSc         
Sub-Investigator: Nishaan Cheddie, MD, FRCSc         
Sub-Investigator: George B Miller, MD, FRCSc         
Sponsors and Collaborators
University of Saskatchewan
  More Information

Responsible Party: Ali Cadili, Clinical Assistant Professor, University of Saskatchewan Identifier: NCT01860469     History of Changes
Other Study ID Numbers: MeshVanco
Study First Received: May 18, 2013
Last Updated: May 18, 2013

Additional relevant MeSH terms:
Hernia, Inguinal
Pathological Conditions, Anatomical
Hernia, Abdominal
Anti-Bacterial Agents
Anti-Infective Agents processed this record on September 21, 2017