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The Effect of neutrophil-to Lymphocyte Ratio in Preeclampsia- Eclampsia

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2013 by Ayse Kirbas, Zekai Tahir Burak Maternity and Teaching Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01856387
First Posted: May 17, 2013
Last Update Posted: March 18, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Ayse Kirbas, Zekai Tahir Burak Maternity and Teaching Hospital
  Purpose
Neutrophil/lymphocyte ratio (NLR) is a marker of systemic inflammation and endothelial dysfunction. In recent years, it has been reported that the individual components of the differential white cell count, specifically the neutrophil and lymphocyte counts,may have clinical utility in predicting diseases. An elevated NLR has been shown to be a prognostic indicator in various malignancies. İn the literature, many studies have been shown that NLR have predictive value in determining the prognosis of various diseases (cardiac or noncardiac diseases ). However, little is known about the predictive values of NLR in pregnancy complications. This study aimed to evaluate the potential predictive value of NLR in preeclampsia- eclampsia.

Condition Intervention
Preeclampsia Eclampsia Biological: high neutrophil to lymphocyte ratio Other: normal neutrophil-to Lymphocyte ratio

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: the Predictive Value of neutrophil-to Lymphocyte Ratio on Preeclampsia- Eclampsia

Resource links provided by NLM:


Further study details as provided by Ayse Kirbas, Zekai Tahir Burak Maternity and Teaching Hospital:

Primary Outcome Measures:
  • the effect of neutrophil lymphocyte ratio in preeclampsia eclampsia [ Time Frame: up to 6 months ]
    during 6 months ,the patients who was recorded with preeclampsi/eclampsia at our hospital ,first trimester whole blood count was taken and neutrophil lymphocyte ratio was calculated and recorded


Biospecimen Retention:   None Retained
whole blood, serum, white cells

Estimated Enrollment: 600
Study Start Date: May 2013
Estimated Study Completion Date: May 2014
Estimated Primary Completion Date: April 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
normal pregnancy outcomes
do not expect poor pregnancy outcomes on normal patients
Biological: high neutrophil to lymphocyte ratio Other: normal neutrophil-to Lymphocyte ratio
adverse pregnancy outcome
high ratio of Neutrophil / lymphocyte ratio may predict preeclampsia eclampsia
Biological: high neutrophil to lymphocyte ratio Other: normal neutrophil-to Lymphocyte ratio

Detailed Description:

In recent years, have been reported that the individual components of the differential white cell count, specifically the neutrophil and lymphocyte counts, may have clinical utility in predicting diseases.

An elevated NLR has been shown to be a prognostic indicator in various malignancies. İn the literatüre have been shown that NLR have predictive value in determining the prognosis of various diseases (cardiac or noncardiac diseases.However, little is known about the predictive values of NLR and PLR in gestational DM, preeclampsia and the other pregnancy complications.

Retrospective data were collected for patients who was diagnosed with , preeclampsia- eclampsia, The NLR was defined as the absolute neutrophil count divided by the absolute lymphocyte count.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
first trimester pregnant
Criteria

Inclusion Criteria:

pregnant women who developing preeclampsia eclampsia at pregnancy

Exclusion Criteria:

Known chronically maternal disease multiple pregnancy older than 40 years old

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01856387


Locations
Turkey
Zekai Tahir Burak Maternity Teaching Hospital Recruiting
Ankara, Turkey
Contact: ayse kirbas    + 90 0 533 646 92 13    ayseozdemirkirbas@hotmail.com   
Contact: ali ersoy    + 90 312-306-5000      
Sub-Investigator: aliozgur ersoy         
Sponsors and Collaborators
Zekai Tahir Burak Women's Health Research and Education Hospital
Investigators
Principal Investigator: ayse kirbas Zekai Tahir Burak Women's Health Research and Education Hospital
  More Information

Responsible Party: Ayse Kirbas, Ayse Kirbas, MD, Zekai Tahir Burak Maternity and Teaching Hospital
ClinicalTrials.gov Identifier: NCT01856387     History of Changes
Other Study ID Numbers: Zekai Tahir Burak
First Submitted: May 4, 2013
First Posted: May 17, 2013
Last Update Posted: March 18, 2014
Last Verified: May 2013

Keywords provided by Ayse Kirbas, Zekai Tahir Burak Maternity and Teaching Hospital:
preeclampsia
eclampsia
prediction
neutrophil-to Lymphocyte ratio

Additional relevant MeSH terms:
Pre-Eclampsia
Eclampsia
Hypertension, Pregnancy-Induced
Pregnancy Complications