Bone Strength After Spinal Cord Injury
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|ClinicalTrials.gov Identifier: NCT01853488|
Recruitment Status : Completed
First Posted : May 15, 2013
Last Update Posted : November 26, 2015
After a traumatic spinal cord injury, a severe bone loss in the paralyzed extremities is observed. This leads to a osteoporosis which is connected to a high fracture risk.
To compare the two measurement methods DEXA and pQCT concerning optimal diagnostics and assessment of fracture risk in subjects with spinal cord injury.
250 women and 250 men (age≥18, any AIS-classification) with an acute or chronic spinal cord injury will be recruited for this study. For a reference group, 500 able-bodied persons will be measured analogously.
Using DEXA-Osteodensitometry, bone parameters of the lumbar vertebral column, proximal femur, distal radius, distal tibia and knee area will be assessed. Additionally, geometric bone parameters of the tibia will be measured by using pQCT. All measurements will be done unilaterally. For the assessment of potential risk factors for reduced bone stiffness after spinal cord injury a questionnaire will be used.
|Condition or disease||Intervention/treatment|
|Spinal Cord Injury||Radiation: DXA Radiation: pQCT|
|Study Type :||Observational|
|Actual Enrollment :||273 participants|
|Observational Model:||Case Control|
|Official Title:||Impact of Spinal Cord Injury on Bone Strength in Paralysed Extremities.|
|Study Start Date :||October 2010|
|Actual Primary Completion Date :||November 2015|
|Actual Study Completion Date :||November 2015|
Spinal Cord Injury
Persons with spinal cord injury Osteodensitometry DXA pQCT
Reference population (able-bodied) Osteodensitometry DXA pQCT
- Bone parameters [ Time Frame: just one timepoint ]Measurement of the extremities with DEXA and pQCT
- Fractures [ Time Frame: just one timepoint (questionnaire) ]Number of fractures since SCI
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01853488
|Nottwil, Lucerne, Switzerland, 6207|
|Principal Investigator:||Angela Frotzler, PhD||Swiss Paraplegic Centre Nottwil|