Repetitive Transcranial Magnetic Stimulation for Freezing of Gait

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT01853150
Recruitment Status : Recruiting
First Posted : May 14, 2013
Last Update Posted : August 4, 2016
Information provided by (Responsible Party):
Suk Yun Kang, Dongtan Sacred Heart Hospital

Brief Summary:
Freezing of gait (FOG) means that patients cannot walk without any known causes, other than parkinsonism, which is very disabling symptom. Patients descirbe their feeling of the feet suddenly being glued to the floor. Transcranial magnetic stiumation is a noninvasive procedure using electromagnetic induction to stimulate brain. Transcranial magnetic stiumation (rTMS) can selectively change brain activity to enhance desired effects. The aim of this study is to the therapeutic effect of rTMS for the FOG.

Condition or disease Intervention/treatment Phase
Parkinsonian Disorders Device: rTMS Motor cortex Device: rTMS Supplementary motor area Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Repetitive Transcranial Magnetic Stimulation for Freezing of Gait
Study Start Date : April 2013
Estimated Primary Completion Date : December 2018

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: rTMS Motor cortex
rTMS will be applied over the motor cortex
Device: rTMS Motor cortex
Active Comparator: rTMS Supplementary motor area
rTMS will be applied over the supplementary motor area
Device: rTMS Supplementary motor area

Primary Outcome Measures :
  1. The number of steps [ Time Frame: 2 days ]
    The number of steps during the stand-walk-sit (SWS) test

Secondary Outcome Measures :
  1. The completion time during the SWS test [ Time Frame: 2 days ]
  2. Freezing episodes of gait trajectory [ Time Frame: 2 days ]
  3. Patient and Clinical Global Impression Scale [ Time Frame: 2 days ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Parkinson's disease or Primary progressive freezing of gait
  • age 18 and older
  • Freezing of gait

Exclusion Criteria:

  • pregnant or any, other medical, surgical, neurological or psychiatric conditions
  • other restrictions which prevent you from undergoing TMS recording, such as; surgically or traumatically implanted foreign bodies such as a pacemaker, an implanted medication pump, a metal plate in the skull, or metal inside the skull or eyes (other than dental appliances or fillings), and/ or heart/cardiac lines
  • any past or current history of seizure disorder or epilepsy
  • unable to give informed consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01853150

Contact: Suk Yun Kang, MD, PhD +82-31-8086-2310

Korea, Republic of
Dongtan Sacred Heart Hospital Recruiting
Hwaseong Si, Gyeonggi-Do, Korea, Republic of, 445-170
Sponsors and Collaborators
Dongtan Sacred Heart Hospital

Responsible Party: Suk Yun Kang, MD, PhD, Dongtan Sacred Heart Hospital Identifier: NCT01853150     History of Changes
Other Study ID Numbers: 2013-022
First Posted: May 14, 2013    Key Record Dates
Last Update Posted: August 4, 2016
Last Verified: August 2016

Additional relevant MeSH terms:
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders