Radiofrequency Ablation for Liver Abscesses From Chronic Granulomatous Disease

• INCLUSION/ELIGIBILITY CRITERIA:

A patient will be included if he or she meets all of the following criteria:

1. Has documented chronic granulomatous disease
2. Age 18 - 75
3. Has a liver abscess infected with Staphylococcus aureus, but is not an optimal candidate for curative surgical resection either due to location of disease, multiplicity of disease, or previous surgery or other comorbidities, such as pulmonary insufficiency, or has other contraindications to general anesthesia or perioperative management or refuses surgery.
4. Is willing to return to NIH for imaging scans
5. Is willing to undergo testing or procedures associated with this protocol
6. Has failed long term antibiotic treatment and abscess drainage if applicable.

EXCLUSION CRITERIA:

A patient will be excluded if he or she satisfies 1 or more of the following criteria:

1. Positive results for toxin-producing bacteria obtained from liver biopsy in the pertinent abscess.
2. Is a good candidate for liver-curative open surgical resection and does not refuse the surgery
3. Is not a candidate for RFA therapy due to lesion size, location, and/or infection with a non staphylococcal bacteria.
4. Has a prothrombin time (PT) or partial thromboplastin time (PTT) >1.5 times normal (except in patients who have a known lupus anticoagulant or other condition which a hematologist deems will not cause excessive bleeding despite the abnormal coagulation parameters).
5. Has a platelet count <50,000/mm(3) which cannot be maintained despite platelet transfusions.
6. If you are pregnant.
7. Any condition that, in the investigator s opinion, places the patient at undue risk by participating in the study

Please Note: Co-morbidities in critically ill patients will not themselves constitute exclusion criteria because the cause of their illness/condition may require the use of RFA as a less invasive treatment than surgery.