Comparison of Epidural and TAP Block in Abdominal Surgery

This study is not yet open for participant recruitment. (see Contacts and Locations)
Verified July 2013 by University of Nebraska
Information provided by (Responsible Party):
Thomas Nicholas IV MD, University of Nebraska Identifier:
First received: April 25, 2013
Last updated: July 3, 2013
Last verified: July 2013

This study intends to examine this rational by comparing the infiltrative transversusabdominis plane (TAP) block with liposomal bupivacaine to EA in major abdominal surgery . The efficacy of the TAP block for abdominal surgery is well documented in the literature (McDonnell 2007) (Kadam 2011), but there are no studies utilizing long-acting bupivacaine. The investigators believe the primary outcome will demonstrate no difference between the two in terms of pain scores and opioid consumption. The investigators anticipate that patients who have undergone TAP blocks will have improved secondary outcomes with respect to a decreased costs, urinary retention, and hypotension.

Condition Intervention
Pain Management
General Surgery
Drug: Epidural
Drug: TAP Block

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Comparison of Epidural Analgesia With Bilateral Dual TAP Infiltration Block With Liposomal Bupivacaine in Patients With Major Abdominal Surgery

Further study details as provided by University of Nebraska:

Primary Outcome Measures:
  • Difference between the two in terms of pain scores andopioid consumption [ Time Frame: one year ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • patients who have undergone TAP blocks will have improved secondary outcomes with respect to a decreased costs, urinary retention, and hypotension. [ Time Frame: 1 year ] [ Designated as safety issue: No ]

Estimated Enrollment: 100
Study Start Date: June 2013
Estimated Study Completion Date: July 2015
Estimated Primary Completion Date: July 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Epidural Drug: Epidural
TAP Block Drug: TAP Block


Ages Eligible for Study:   19 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Adult subjects undergoing major abdominal surgery


Inclusion Criteria:

  • subject >/= 19 years of age
  • Undergoing major abdominal surgery
  • able to provide written informed consent

Exclusion Criteria:

  • chronic opioid use
  • allergies to amide anesthetics
  • inability to undergo general anesthesia
  • pregnancy
  • any existence of contraindications to regional anesthesia in the presence of antiplatelet or anticoagulative drugs
  • or evidence of gross neurological dysfunction of the lower extremity
  Contacts and Locations
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Please refer to this study by its identifier: NCT01848951

United States, Nebraska
University of Nebraska Medical Center Not yet recruiting
Omaha, Nebraska, United States, 68105
Contact: Stacey L Therrien, BS    402-559-2905   
Sponsors and Collaborators
University of Nebraska
  More Information

No publications provided

Responsible Party: Thomas Nicholas IV MD, Assistant Professor, University of Nebraska Identifier: NCT01848951     History of Changes
Other Study ID Numbers: 287.13.FB
Study First Received: April 25, 2013
Last Updated: July 3, 2013
Health Authority: United States: Institutional Review Board processed this record on May 21, 2015