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The Effects of Dietary Fiber in CKD: A Systematic Review and Meta-analysis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01844882
Recruitment Status : Completed
First Posted : May 3, 2013
Last Update Posted : November 21, 2014
Information provided by (Responsible Party):
Unity Health Toronto

Brief Summary:
Chronic kidney disease (CKD) is a debilitating condition in which there is a gradual decline of renal function associated with increased overall mortality. Most dietary guidelines for CKD focus on limiting protein intake (nitrogen) and high phosphorus-containing foods. However, increasing dietary fiber has been proposed to increase fecal nitrogen excretion which may ameliorate the progress of CKD. We therefore plan to conduct a systematic review and meta-analysis on clinical trials to assess the effect of fiber on urea and creatinine as classical markers of a state of uremia in individuals with CKD. We hypothesize that increasing fiber intakes will improve urea and creatinine levels in individuals with CKD.

Condition or disease
Chronic Kidney Disease

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Study Type : Observational
Actual Enrollment : 1 participants
Time Perspective: Retrospective
Official Title: The Effects of Dietary Fiber on Uremic Retention Solutes in CKD: A Systematic Review and Meta-analysis
Study Start Date : January 2012
Actual Primary Completion Date : August 2013
Actual Study Completion Date : August 2013

Resource links provided by the National Library of Medicine

Chronic Kidney Disease

Primary Outcome Measures :
  1. Creatinine [ Time Frame: 1.5 years ]
  2. urea [ Time Frame: 1.5 years ]

Secondary Outcome Measures :
  1. Phosphorus [ Time Frame: 1.5 years ]

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
patients with Chronic Kidney Disease (CKD)

Inclusion Criteria:

  • Dietary trials in humans
  • Randomized treatment allocation
  • Suitable control (low fiber)
  • viable endpoint data

Exclusion Criteria:

  • Non-human studies
  • Nonrandomized treatment allocation
  • Lack of a suitable control (high protein)
  • no viable endpoint data
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Unity Health Toronto Identifier: NCT01844882    
Other Study ID Numbers: SMH-CKD-2013
First Posted: May 3, 2013    Key Record Dates
Last Update Posted: November 21, 2014
Last Verified: November 2014
Keywords provided by Unity Health Toronto:
The effects
kidney function
CKD patients
Additional relevant MeSH terms:
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Kidney Diseases
Renal Insufficiency, Chronic
Urologic Diseases
Renal Insufficiency