Effect of Parecoxib on the Change of Shoulder Pain Threshold After Gynecological Laparoscopies
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|ClinicalTrials.gov Identifier: NCT01843010|
Recruitment Status : Completed
First Posted : April 30, 2013
Last Update Posted : February 19, 2014
|Condition or disease||Intervention/treatment||Phase|
|Postoperative Pain Management, Pain Threshold, Shoulder Pain, Laparoscopies||Drug: Parecoxib Drug: Placebo||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||140 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Care Provider, Outcomes Assessor)|
|Official Title:||Effect of Parecoxib on the Change of Shoulder Pain Threshold After Gynecological Laparoscopies|
|Study Start Date :||May 2013|
|Actual Primary Completion Date :||November 2013|
|Actual Study Completion Date :||November 2013|
Active Comparator: Parecoxib
Intravenously Parecoxib 40mg at 30min before intubation, 8h and 20h after surgery.
Parecoxib 40mg will be intravenously infused.
Placebo Comparator: Placebo
Normal saline 5ml will be intravenously infused at the same time points., respectively.
Normal saline 5ml will be intravenously infused.
- The change of shoulder pressure pain threshold [ Time Frame: The pressure pain thresholds are measured at the day before surgery, 24h and 48h after surgery ]The patients keep sitting position, and the pressure pain thresholds are measured twice at a fixed point in bilateral levator scapulae, supraspinatus, pectoralis major and flexor carpi ulnaris with a pressure algometer (FPX25, Wagner Instruments, USA) by an independent doctor.
- The severity of shoulder pain [ Time Frame: At the day before surgery, 24h and 48h after surgery ]The patients are asked to rate the severity of shoulder pain via a visual analog scale (VAS) ranging from no pain (0) to worst possible pain (10) by another independent doctor.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01843010
|Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University.|
|Guangzhou, Guangdong, China, 510089|
|Study Director:||Ke xuan Liu, M.D and Ph.D||1st affiliated hospital of Sun Yat-sen university|