Effect of Parecoxib on the Change of Shoulder Pain Threshold After Gynecological Laparoscopies
|ClinicalTrials.gov Identifier: NCT01843010|
Recruitment Status : Completed
First Posted : April 30, 2013
Last Update Posted : February 19, 2014
|Condition or disease||Intervention/treatment||Phase|
|Postoperative Pain Management, Pain Threshold, Shoulder Pain, Laparoscopies||Drug: Parecoxib Drug: Placebo||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||140 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Care Provider, Outcomes Assessor)|
|Official Title:||Effect of Parecoxib on the Change of Shoulder Pain Threshold After Gynecological Laparoscopies|
|Study Start Date :||May 2013|
|Actual Primary Completion Date :||November 2013|
|Actual Study Completion Date :||November 2013|
Active Comparator: Parecoxib
Intravenously Parecoxib 40mg at 30min before intubation, 8h and 20h after surgery.
Parecoxib 40mg will be intravenously infused.
Placebo Comparator: Placebo
Normal saline 5ml will be intravenously infused at the same time points., respectively.
Normal saline 5ml will be intravenously infused.
- The change of shoulder pressure pain threshold [ Time Frame: The pressure pain thresholds are measured at the day before surgery, 24h and 48h after surgery ]The patients keep sitting position, and the pressure pain thresholds are measured twice at a fixed point in bilateral levator scapulae, supraspinatus, pectoralis major and flexor carpi ulnaris with a pressure algometer (FPX25, Wagner Instruments, USA) by an independent doctor.
- The severity of shoulder pain [ Time Frame: At the day before surgery, 24h and 48h after surgery ]The patients are asked to rate the severity of shoulder pain via a visual analog scale (VAS) ranging from no pain (0) to worst possible pain (10) by another independent doctor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01843010
|Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University.|
|Guangzhou, Guangdong, China, 510089|
|Study Director:||Ke xuan Liu, M.D and Ph.D||1st affiliated hospital of Sun Yat-sen university|