Changes in Body- and Liver-composition During Low Calorie Diet in Morbidly Obese
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|ClinicalTrials.gov Identifier: NCT01842425|
Recruitment Status : Unknown
Verified April 2013 by DEdholm, Uppsala University.
Recruitment status was: Recruiting
First Posted : April 29, 2013
Last Update Posted : April 30, 2013
|Condition or disease|
Preoperative weight loss prior to laparoscopic gastric bypass is desirable as this reduces liver volume and thus facilitates the visualization of the gastro-esophageal junction. Weight loss is often achieved through low-calorie diet (LCD); however the ideal duration of LCD treatment is unknown.
Morbidly obese female patients awaiting laparoscopic gastric bypass are recruited. They are, as all our patients, treated during four weeks with LCD to achieve a decrease in liver size. During this period they are examined on day 0, 3, 7, 14 and 28 after commencing LCD.
At each evaluation, body composition is assessed through bioelectric impedance analysis (BIA), liver volume and intrahepatic fat through magnetic resonance imaging. A questionnaire regarding quality of life and LCD-related symptoms is administered as well. At surgery two samples of subcutaneous fat and one sample of omental fat is taken.
We do not assign patients to different treatments, instead all are treated similarly according to our routine preoperative regimen.
|Study Type :||Observational|
|Estimated Enrollment :||30 participants|
|Official Title:||Changes in Body- and Liver-composition During Low Calorie Diet in Morbidly Obese|
|Study Start Date :||October 2012|
|Estimated Primary Completion Date :||December 2015|
|Estimated Study Completion Date :||December 2015|
- Liver volume [ Time Frame: From baseline to after four weeks ]
- Composition of body fat in subcutaneous and omental fat [ Time Frame: At surgery ]
- Changes in body composition [ Time Frame: Baseline to 4 weeks ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01842425
|Department of surgery, Akademiska sjukhuset||Recruiting|
|Uppsala, Sweden, S-75185|
|Contact: David Edholm, Dr 0046 733127764 email@example.com|
|Principal Investigator: David Edholm, Dr|
|Principal Investigator:||David Edholm, MD||Department of Surgery|