To Compare the Strategies of Universal Antibiotic Prophylaxis Versus Screen-and-treat in Reducing Infective Complications and Re-infection in Women Who Undergo Termination of Pregnancy
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|ClinicalTrials.gov Identifier: NCT01842100|
Recruitment Status : Completed
First Posted : April 29, 2013
Last Update Posted : April 29, 2013
|Condition or disease||Intervention/treatment||Phase|
|Induced Abortion Postaboral Pelvic Inflammatory Disease Sexually Transmitted Infections||Drug: Universal antibiotic prophylaxis Other: Screen-and-treat||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||2193 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||To Compare the Strategies of Universal Antibiotic Prophylaxis Versus Screen-and-treat in Reducing Infective Complications and Re-infection in Women Who Undergo Termination of Pregnancy|
|Study Start Date :||September 1999|
|Actual Primary Completion Date :||February 2006|
|Actual Study Completion Date :||February 2006|
Active Comparator: Universal antibiotic prophylaxis
In the universal prophylaxis group, all women received doxycycline 100 mg twice daily for 7 days starting on the day of induced abortion. Screening for sexually transmitted diseases was done as baseline but the results were not revealed to the patients.
Drug: Universal antibiotic prophylaxis
100 mg twice daily for 7 days starting on the day of induced abortion
Active Comparator: Screen-and-treat
In the screen-and-treat group, the results of screening for sexually transmitted infections (STI) were revealed to the patients. They would only receive appropriate specific antibiotics treatment only if they were screened positive for any of the STIs. If they were found to have STI, their sexual partners would also be referred to the local social hygiene clinics for contact tracing and treatment. Contraception by barrier methods would also be advised.
Specific antibiotic treatment was only given if the women was found to have sexually transmitted infection(s) on screening.
- Rate of postabortal inflammatory disease 6 weeks after induced abortion. [ Time Frame: 6 weeks after induced abortion. ]
- Rate of re-infection by sexually transmitted infections 24 weeks after induced abortion. [ Time Frame: 24 weeks after induced abortion. ]
- Proportion of women having abstinence from sexual intercourse or using condom at 6 weeks, 24 weeks and 1 year after induced abortion. [ Time Frame: 6 weeks, 24 weeks and 1 year after induced abortion ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01842100
|China, Hong Kong|
|Queen Mary Hospital|
|Hong Kong, Hong Kong, China|
|Principal Investigator:||Sofie SF Yung, MBBS, MRCOG||The University of Hong Kong|