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Trial record 24 of 37 for:    conjugated linoleic acid

CLA Metabolism and Effects on Human Health

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ClinicalTrials.gov Identifier: NCT01841645
Recruitment Status : Completed
First Posted : April 26, 2013
Last Update Posted : May 3, 2013
Sponsor:
Collaborator:
Rio de Janeiro State University
Information provided by (Responsible Party):
Alexandre Guedes Torres, Universidade Federal do Rio de Janeiro

Brief Summary:
The purpose of the study is to investigate the effects of Conjugated Linoleic Acid (CLA) from dairy products on fatty acid metabolism and human health. A CLA depletion-repletion study was carried out with healthy volunteers. CLA depletion was achieved through an eight-week dairy fat restriction, followed by an eight-week repletion period consisting of intake of a butter naturally enriched with CLA. Changes in body composition, fasting glucose and insulin, inflammatory mediators, cell membranes' stability, plasma lipid levels and fatty acid composition of lipid classes are evaluated after depletion and repletion phases.

Condition or disease Intervention/treatment Phase
Dietary Modification Inflammation Body Composition, Beneficial Dietary Supplement: CLA depletion-repletion Not Applicable

Detailed Description:
After collecting baseline blood samples, CLA-depletion phase started with dietary orientation, by a registered dietitian, to the study subjects (n=29) to exclude from their diets any type of dairy fat for the following 8 weeks. Blood samples were taken at the end of CLA-depletion, and CLA-repletion phase was initiated by dietitians' instructions: volunteers returned to their regular diets, and additionally consumed a CLA-enriched butter for another 8-week period. Blood samples were taken at the end of the CLA-repletion phase. The effects of CLA on the following parameters were evaluated: inflammatory mediators; fatty acid composition of erythrocytes, plasma phospholipids and cholesterol esters; body composition; clinical factors associated with the metabolic syndrome and indicators of cell membranes' stability.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 29 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Conjugated Linoleic Acid (CLA) Depletion-repletion: Metabolism and Bioactivity in Humans
Study Start Date : July 2009
Actual Primary Completion Date : October 2010
Actual Study Completion Date : October 2010

Arm Intervention/treatment
CLA depletion-repletion Dietary Supplement: CLA depletion-repletion



Primary Outcome Measures :
  1. Fatty acid metabolism and inflammatory mediators were accompanied during a CLA depletion-repletion dietary intervention [ Time Frame: 16 weeks ]
    Changes in body composition, fasting glucose and insulin, inflammatory mediators, cell membrane stability, plasma lipid levels and fatty acid composition of lipid classes were evaluated before and after depletion and repletion phases.



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Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy volunteers;
  • 20 to 40 years;
  • BMI between 18.0 and 29.9 kg/m2.

Exclusion Criteria:

  • Use of dietary supplements;
  • Smoker;
  • Alcoholic;
  • Under medication;
  • History of chronic disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01841645


Locations
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Brazil
Federal University of Rio de Janeiro
Rio de Janeiro, Brazil, 21941-909
Sponsors and Collaborators
Alexandre Guedes Torres
Rio de Janeiro State University
Investigators
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Principal Investigator: Alexandre G Torres, DSc Universidade Federal do Rio de Janeiro

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Responsible Party: Alexandre Guedes Torres, Professor Alexandre Guedes Torres, Universidade Federal do Rio de Janeiro
ClinicalTrials.gov Identifier: NCT01841645     History of Changes
Other Study ID Numbers: AGT2013
First Posted: April 26, 2013    Key Record Dates
Last Update Posted: May 3, 2013
Last Verified: May 2013
Keywords provided by Alexandre Guedes Torres, Universidade Federal do Rio de Janeiro:
CLA-enriched butter
CLA metabolism
inflammation
Additional relevant MeSH terms:
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Inflammation
Pathologic Processes