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Cardiac Functions in Living Donor Liver Transplant Recipients. An Echocardiographic Study.

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ClinicalTrials.gov Identifier: NCT01840514
Recruitment Status : Unknown
Verified October 2013 by Amr Mohamed Yassen, Mansoura University.
Recruitment status was:  Recruiting
First Posted : April 25, 2013
Last Update Posted : October 8, 2013
Sponsor:
Information provided by (Responsible Party):
Amr Mohamed Yassen, Mansoura University

Brief Summary:
The stress of orthotopic living donor liver transplantation in patients with cirrhosis could induce worsening of an already recorded myocardial dysfunction or may be associated with a new myocardial dysfunction in patients previously having normal myocardial functions, therefore this study will be designed for intra-operative detection of new onset ventricular dysfunction or worsening of already diagnosed ventricular dysfunction in living donor liver transplant recipient and the possible contribution of several hemodynamic and oxygenation parameters in the generation of any cardiovascular function impairment will be also investigated and to determine the impact of ventricular dysfunction on early (7 PO days) graft function, 28 days survival and patient outcomes.

Condition or disease
Liver Transplant

Study Type : Observational [Patient Registry]
Estimated Enrollment : 60 participants
Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 1 Day
Official Title: Cardiac Functions in Living Donor Liver Transplant Recipients. An Echocardiographic Study.
Study Start Date : December 2012
Estimated Primary Completion Date : April 2015
Estimated Study Completion Date : September 2015

Resource links provided by the National Library of Medicine

U.S. FDA Resources




Primary Outcome Measures :
  1. hemodynamic monitoring [ Time Frame: intraoperative ]

Secondary Outcome Measures :
  1. graft function [ Time Frame: 7 days ]

Other Outcome Measures:
  1. survival [ Time Frame: 28 days ]


Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
recipient of living donor liver
Criteria

Inclusion Criteria:

  • all adult recipient

Exclusion Criteria:

  • massive blood transfusion
  • grade III esophageal varices

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01840514


Contacts
Contact: amr M yassen, MD +201001497044 amryassen@hotmail.com
Contact: Waleed R Elsarraf, MD +201222322727 welsarraf@yahoo.com

Locations
Egypt
Liver transplantation program - Gastroenterology surgical center Recruiting
Mansoura, Dakahlia, Egypt, 35511
Contact: Amr M Yassen, MD    +201001497044    amryassen@hotmail.com   
Contact: Waleed R alsarraf, MD    +201222322727    welsarraf@yahoo.com   
Principal Investigator: Amr Yassen, MD         
Liver transplantation project - Gastroenterology surgical center - Mansoura university Recruiting
Mansoura, Dakahlia, Egypt, 35511
Contact: Amr M Yassen, MD    +201001497044    amryassen@hotmail.com   
Contact: Waleed R Elsarraf, MD    +201222322727    welsarraf@yahoo.com   
Sub-Investigator: Amr M Yassen, MD         
Sponsors and Collaborators
Mansoura University
Investigators
Principal Investigator: amr yassen, MD Liver transplant program, mansoura faculty of medicine

Responsible Party: Amr Mohamed Yassen, professor, Mansoura University
ClinicalTrials.gov Identifier: NCT01840514     History of Changes
Other Study ID Numbers: 1982
First Posted: April 25, 2013    Key Record Dates
Last Update Posted: October 8, 2013
Last Verified: October 2013

Keywords provided by Amr Mohamed Yassen, Mansoura University:
recipient